摘要
目的:探讨阿托伐他汀钙预防高危患者急性脑梗死复发的临床药理疗效,观察阿托伐他汀钙对脑梗死患者血脂、血清炎性因子及颈动脉粥样硬化的影响,以指导临床用药。方法:156例首发急性脑梗死患者分为两组:对照组(n=66)给予常规治疗,观察组(n=90)加服阿托伐他汀钙20mg/d,疗程6个月。全部患者治疗前、治疗后6个月均测定血脂、炎性因子水平及颈动脉粥样硬化情况。结果:治疗6个月后观察组血脂、血清炎性因子水平及IMT、颈动脉斑块面积明显优于对照组(P<0.05或0.01);观察组6个月脑梗死复发率显著低于对照组(5.56%vs.21.2%,P<0.01)。结论:阿托伐他汀钙能够显著改善脑梗死患者血脂、血清炎性因子水平,稳定颈动脉粥样硬化斑块,促进斑块逆转,降低脑梗死复发风险。
Oblective： To explore the clinical pharmacological effects of atorvastatm on preventing relapsed cerebral infarction in high-risk patient, and to investigate the influence of atorvastatin on the in- flammatory factors, serum lipids and carotid artery atherosclerosis in patients with cerebral infarction. Methods： A total of I56 patients with the first onset of acute cerebral infarction were divided into control group （n=66） and observation group （n=90）. The control group was given conventional therapy, observation group take atorvastatin 20 mg/d, both for 6 months. Serum lipids and inflammatory factors, the carotid artery intimal and media thickness （IMT） and plaque areas were measured before and 6 months after treatment. Results： The improvement in serum lipids, carotid artery atherosclerosis, IMT and carotid artery plaque area in observation group were better than those in the control group （P〈0.05 or 0. 01）. The six-month recurrence rate of observation group was significantly lower than that of the control group （5.56% vs. 21.2%, P〈0.01）. Conclusion- Atorvastatin calcium can significantly improve endothelial function, lipid levels and carotid atherosclerotic plaque stability in patients with acute cerebral infarction, and promote plaque regression, reduced the recurrence rate of cerebral infarction.
出处
《海南医学院学报》
CAS
2013年第5期596-599,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210622)~~
关键词
阿托伐他汀钙
高危患者
急性脑梗死
Atorvastatin
High-risk patient
Acute cerebral infarction
