摘要
目的对肝硬化上消化道出血并发医院感染患者使用抗菌药物进行观察分析,为临床治疗提供参考。方法选择医院2007年1月-2011年12月收治的130例肝硬化合并上消化道出血的患者作为研究对象,将所有患者随机分为抗菌药物预防组和非抗菌药物预防组,抗菌药物预防组患者入院后在常规治疗基础上加用抗菌药物预防医院感染,非抗菌药物组不使用抗菌药物,对比1个月内两组患者发生医院感染,消化道再出血及感染组中病原菌的分布情况。结果抗菌药物预防组发生感染者6例,感染率为9.23%,未使用抗菌药物预防组患者发生感染者15例,感染率为23.07%,两组比较差异有统计学意义(P<0.05);发生医院感染者21例,上消化道出血复发患者8例,发生率为38.09%;未发生医院感染的患者109例中,消化道出血发生率4.5%,显著低于发生医院感染的患者组(P<0.05)。结论针对肝硬化合并上消化道出血患者应用抗菌药物,可以显著降低医院感染与上消化道再出血发生率,具有临床应用价值。
OBJECTIVE To study the effect of antibiotics prophylaxis on noscocomial infections in liver cirrhotic patients with acute upper gastrointestinal hemorrhage so as to provide basis for the clinical treatment.METHODS From Dec 2007 to Feb 2011,totally 130 patients with liver cirrhosis combined with upper gastrointestinal bleeding were selected as the research objects,all the patients were randomly divided into the antibiotics prophylaxis group and the non-antibiotics group.The antibiotics prophylaxis group was treated with the antibiotics based on the conventional treatment after the admission,while the non-antibiotics group did not use any antibiotics.The incidence rate of the nosocomial infections within one month was compared between the two groups,and the re-hemorrhage of gastrointestinal tract and the distribution of the pathogens causing infections were compared as well.RESULTS There were 6（9.23%） patients with infections in the antibiotics prophylaxis group and 15（23.07%） patients with infections in the non-antibiotics group,with statistical significance（P0.05）.Of 21 patients with nosocomial infections,there were 8（38.09%） patients with recurrence of upper gastrointestinal bleeding.Among the 109 patients without nosocomial infections,the incidence rate of the gastrointestinal tract bleeding was 4.5%,significantly lower than that of the patients with nosocomial infections（P0.05）.CONCLUSION For the hepatocirrhosis patients combined with upper gastrointestinal bleeding,the use of antibiotics can significantly reduce the incidence of nosocomial infections as well as the recurrence of upper gastrointestinal bleeding,with significant value in clinical application.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第9期2064-2066,共3页
Chinese Journal of Nosocomiology
关键词
肝硬化
上消化道出血
医院感染
抗菌药物
预防
Cirrhosis upper gastrointestinal bleeding
Nosocomial infection
Antibiotics
Prevention
