摘要
目的探讨幽门螺杆菌(Hp)感染对动脉粥样硬化的影响,为其临床防治提供依据。方法共纳入220例动脉粥样硬化患者,详细记录其病史及相关信息,所有患者均采用快速尿素酶检测确诊有Hp感染,A组患者100例给予常规降脂等常规治疗方法,B组患者120例在A组治疗基础上给予Hp感染治疗,分别于治疗前、治疗后1月比较两组患者动脉粥样硬化常规指标胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及C-反应蛋白(CRP),并行颈部血管超声检查颈动脉内膜中层厚度(IMT)。结果两组患者治疗后对血脂的影响分析比较发现,治疗前A组TC、TG、LDL-C、HDL-C、CRP及IMT厚度与B组差异无统计学意义;治疗1月后比较,A组TC、TG、LDL-C、HDL-C、CRP及IMT厚度分别为(5.0±0.9)mmol/L、(1.8±0.4)mmol/L、(2.9±0.8)mmol/L、(5.9±2.8)mmol/L、(0.9±0.5)mm,B组分别为(4.2±0.6)mmol/L、(1.1±0.2)mmol/L、(2.2±0.6)mmol/L、(3.2±1.6)mmol/L、(0.5±0.3)mm,B组患者TC、TG、LDL-C、CRP及IMT厚度均有明显下降,而HDL-C(1.2±0.3mmol/L、1.6±0.5mmol/L)有明显增高,与治疗前相比,差异有统计学意义(P<0.05);与A组患者相比,B组患者下降更明显,差异有统计学意义(P<0.05);进一步对Hp感染与各项指标的相关性进行分析显示,给予Hp感染治疗后,动脉粥样硬化程度及炎性因子、血脂有更明显的下降,相关性系数分别为0.71、0.70、0.76、0.72、0.73、0.74(P<0.01)。结论 Hp感染主要是通过引起炎性反应及脂类代谢的异常引起动脉粥样硬化等一系列病理反应的发生参与并促进动脉粥样硬化的发生、发展,在临床工作中,对Hp感染要积极给予治疗及干预,可能降低动脉粥样硬化的发生。
OBJECTIVE To explore the influence of Helicobacter pylori（Hp） infection on the atherosclerosis so as to guide the clinical prevention.METHODS The participants included 220 patients who suffered from the atherosclerosis,the medical history and related information of the patients were recorded in detail.All the patients were diagnosed as Hp infection by rapid urease test,totally 100 cases of patients in the group A were treated with conventional lipid-lowering method,while 120 cases in the group B was given the anti-Hp infection therapy on the basis of treatment of the group A.The atherosclerosis routine indexes including the cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C）,high density lipoprotein（HDL-C） and C-reactie protein（CRP）,parallel neck vascular ultrasound examination of the carotid intima-media thickness（IMT） were compared between the two groups at one month before and after the treatment.RESULTS The analysis of the influence on the blood lipid after the treatment showed that the difference in the TC,TG,LDL-C,hdl-c,CRP or IMT thickness before the treatment between the group A and the group B was not statistically significant;one month after the treatment,the TC,TG,LDL-C,HDL-C,CRP and IMT thickness were（5.0±0.9）mmol/L,（1.8±0.4）mmol/L,（2.9±0.8） mmol/L,（5.9±2.8）mmol/L,and（0.9±0.5）mm,respectively in the group A and were（4.2±0.6）mmol/L,（1.1±0.2） mmol/L,（2.2±0.6） mmol/L,（3.2±1.6） mmol/L,and（0.5±0.3） mm,respectively of the group B;the TC,TG,LDL-C,CRP and IMT thickness of the group B were significantly decreased,but the HDL-C（1.2±0.3 mmol/L,1.6±0.5 mmol/L） was significantly increased,the difference was statistically significant（P0.05）.As compared with the group A,the group B decreased more significantly,the difference was statistically significant（P0.05）;the further analysis of the correlation between the Hp infection and each index showed that after the anti-Hp infection therapy,the atherosclerosis degree and inflammatory factors,and blood lipid decreased more significantly,and the coefficients were 0.71,0.70,0.76,0.72,0.73,and 0.74,respectively（P0.01）.CONCLUSION The Hp infection can promote the emergence and development of the atherosclerosis by leading to the inflammatory reaction and lipid metabolic abnormalities,thus it is necessary for the hospital to give the positive treatment and intervention to the Hp infection so as to reduce the incidence of atherosclerosis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第9期2072-2073,2076,共3页
Chinese Journal of Nosocomiology
关键词
幽门螺杆菌
动脉粥样硬化
影响
Helicobacter pylori
Atherosclerosis
Influence
