摘要
目的 :观察雷公藤片与泼尼松佐治慢性淋巴细胞性甲状腺炎的临床疗效。方法 :慢性淋巴细胞性甲状腺炎患者 5 0例 ,均为女性 ,无甲状腺功能变化的表现。随机分成两组 :A组、B组各 2 5例。在用左旋甲状腺素片治疗同时 ,A组加用泼尼松片口服 ,B组加用雷公藤片口服。疗程 3个月。观察两组患者治疗前后血T3 、T4 、促甲状腺素 (TSH)、抗甲状腺球蛋白抗体 (TG Ab)、抗甲状腺过氧化酶抗体 (TPO Ab)及甲状腺大小变化。结果 :两组患者治疗前后血T3 、T4 和TSH无明显变化。TG Ab、TPO Ab及甲状腺大小两组间无显著对比性。各组治疗前后差异均有显著性 (P <0 .0 1)。A组患者普遍主诉体重增加。 6例主诉水肿 ,2例因血压偏高而减量、停药。B组患者无明显副作用。结论 :雷公藤片佐治慢性淋巴细胞性甲状腺炎疗效显著 ,且可避免糖皮质激素的副作用。
Objective:To observe the clinical efficiency of Tripterygium Witfondii Hooh F and prednisone in treatment for chronic lymphatic thyroitis(CLT). Methods:Fifty female CLT patients without symptoms resulting from any change of thyroid funtion were divided by random sampling into A and B group(25 patients in each group). All were treated with L T\-4. On this base the patients in A group were plus with prednisone and ones in B with Tripterygium Witfondii Hooh F in three months. The blood T\-3,T\-4,TSH,TG Ab,TPO Ab and the changes of thyroid of the patients were determined before and after treatment. Results:The blood T\-3,T\-4 and TSH had no obvious change before and after medication. There was no difference in TG Ab,TPO Ab and the condition of thyroid compared between two groups,but there were significant differences to these data compared in pairs before and after treating( P <0.01). In A group the patients complained obesity and 6 had edema and 2 weren't given the medication owing to blood hypertension. However,all patients in B group had no side effect during the medical care. Conclusions:The treatment of CLT with Tripterygium Witfondii Hooh F is effective and safe,and may avoid side effect of prednisone. [
出处
《蚌埠医学院学报》
CAS
2000年第4期254-255,共2页
Journal of Bengbu Medical College
