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中药抗心肌缺血再灌注损伤与基因表达的研究进展 被引量:8

Research Progress of Anti-myocardial Ischemia/reperfusion Injury and Gene expression of Traditional Chinese Medicine
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摘要 查阅近几年来有关中药抗实验性心肌缺血再灌注损伤与基因表达的研究文献资料,进行分析、综述。中药可通过上调或下调B-细胞淋巴瘤基因2(Bcl-2),Fas,半胱天冬氨酸家族(Caspase),c-fos,核转录因子(NF-κB),热休克蛋白70(HSP70)等心肌细胞凋亡相关基因表达而发挥抗心肌缺血作用。中药通过调节多种基因的表达来发挥抗心肌缺血作用。目前研究抗心肌缺血再灌注损伤的中药有单体化合物、单味药、复方制剂,取得了可喜成果,但在临床应用中大多都是以复方制剂为主,因此中药复方制剂抗心肌缺血的机制研究是目前也是将来心血管病学的研究热点之一,在研究过程中要结合中医理论的用药指导,遵循严谨的配伍,将中药理论与现代科学研究结合起来,更有助于促进中药学的发展,为临床用药提供科学依据。 To summarize the research progress of anti-myocardial ischemia/reperfusion injury and gene expression of traditional Chinese medicine.Analyze and review the recently article based on anti-myocardial ischemia/reperfusion injury and gene expression of traditional Chinese medicine. traditional Chinese medicine could upregulate or downregulate the genes expression,like Bcl-2, Fas, Caspase, c-fos, nuclear factor-κ binding(NF-κB), heat shoch brotein 70(HSP70) which related the apoptosis of myocardial cell and play the role of anti-myocardial ischemia. traditional Chinese medicine play the role of anti-myocardial ischemia through regulating the expression of many genes.
机构地区 青海大学医学院
出处 《中国实验方剂学杂志》 CAS 北大核心 2013年第10期360-364,共5页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金项目(81060368) 青海大学医学院中青年科技项目(2009-KY-06)
关键词 心肌 缺血再灌注损伤 基因表达 myocardium ischemia/reperfusion injury gene expression
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参考文献34

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