摘要
目的研究Bmi-1蛋白在乳腺癌组织中的表达与临床病理学特征的相关性。方法采用免疫组织化学方法检测60例乳腺癌组织中Bmi-l蛋白的表达水平,分析Bmi-1蛋白在乳腺癌组织中的表达,并结合乳腺癌患者的临床病理资料分析与其相关性。结果乳腺癌组织中Bmi-1蛋白的阳性表达率为88.3%,Bmi-1蛋白阳性表达与淋巴结转移、肿瘤大小、远处转移及TNM临床分期密切相关(P<0.05),与ER、PR、CerbB-2等临床病理特征无显著性相关(P>0.05)。结论 Bmi-1蛋白的高表达在乳腺癌的发生、发展和转移中起重要作用,提示Bmi-1可能成为预测乳腺癌高度转移的新标志物。
Objective This study was to investigate the correlation between the expression and pathological charaeteristics of Bmi-1 Protein in breast cancer. Methods The expression of Bmi-1 protein in 60 specimens of breast cancer was detected by immunohistochemistry. The correlation of Bmi 1 expression to clinic pathologic features of breast cancer was analyzed. Results The intensive positive rate of/3mi-1 in breast cancer was 88.3%. The intensive expression of Bmi-i was positively correlated to lymph node metastasis, tumor size, metastasis and Clinical stage （TNM） （ P （ 0. 05 ）, but not to estrogen receptor （ ER）, progesterone receptor （ PR）, and C-erbB-2 expression（P〈0.05）. Conclusion The high expression of Bmi-1 protein plays important roles in the development and the metastasis of breast cancer, Bmi-1 may serve as a new molecular marker of metastas is of breast cancer.
出处
《成都医学院学报》
CAS
2013年第2期165-167,共3页
Journal of Chengdu Medical College
基金
宁波卫生局宁波科学技术局课题项目(NO:2010A21)
