摘要
目的探讨血清超敏C-反应蛋白(hs-CRP)、肌钙蛋白Ⅰ(cTnⅠ)及肌酸激酶同工酶(CK-MB)联合检测在急性心肌梗死(AMI)诊断中的临床价值。方法对38例心肌梗死胸骨后疼痛发作2～6h的患者及48例心肌梗死胸骨后疼痛发作12～24h的患者采用免疫散射比浊定量法检测其血清CPR,采用免疫抑制法检测CK-MB,采用免疫荧光法检测其血清cTnⅠ,并与39例正常对照组进行比较。结果两AMI组患者的CRP、cTnⅠ及CK-MB浓度较正常对照组高;联合检测CRP+CK-MB、CRP+cTnⅠ+CK-MB、cTnⅠ+CRP阳性检出率均为100.0%。结论联合检测hs-CRP、cTnⅠ在AMI早期诊断中有很高的特异性及灵敏度,可作为AMI的预后监测及疗效观察的指标。
Objective To investigate the value of measuring serum level of hs-CRP, CK-MB and cTnl in patient, s with acute myocardial infarction in early stage. Methods The serum levels of hs-CRP, CK-MB and eTnI were measured in 38 patients with AMI in 2-6 hours after the onset of symptoms and 48 cases in 12-24 ilours after the onset of symptoms and 39 healthy people respectively. The serum CPR was detected by immune scattering turbidimetric quantitative method, CK-MB was detected by immunosuppression, cTnI was detected by innnunofluorescenee assay. The resuhs were compared with 39 cases of control group. Results In patients with AMI, cTnI, CK-MB and CRP were significantly higher than healthy individuals. CRP positive rate of combined deteetion of CRP＋CK-MB, CRP＋cTnI＋CK-MB, cTnI＋CRP were all 100.0%. Conclusion The combined detection of serum hs-CRP and cTnl has high specifieity and sensitivity in early diagnosis of AMI, can be used as the prognosis monitoring and curative effect observation index of AMI.
出处
《中国当代医药》
2013年第14期116-117,共2页
China Modern Medicine
关键词
超敏C反应蛋白
肌钙蛋白Ⅰ
肌酸激酶同工酶
急性心肌梗死
High sensitivity e-reactive protein
Cardiae troponin I
Creatine kinase isoenzyme
Acute myocardial infarction
