摘要
目的:观察甘露聚糖肽序贯治疗与放化疗联合应用治疗胃癌的疗效。方法:102例Ⅳ期胃癌住院患者,男性62例,女性40例,平均58岁,随机分为试验组和对照组,各51例。两组给予常规治疗:多西紫杉醇+氟尿嘧啶+顺铂(DCF化疗),试验组加用甘露聚糖肽序贯治疗;对照组加用胸腺肽序贯治疗。观察指标:(1)生存质量:评价中位生存期和治疗结束后1年的生存质量评分。(2)免疫学指标:CD4、CD8、CD4/CD8、外周血白细胞、抗体(IgA、IgG、IgM)、补体(C3)、中性粒细胞;(3)不良反应:恶性呕吐等放化疗常见不良反应。结果:试验组与对照组相比,治疗结束后1年的卡氏评分和中位生存期均有显著性差异(P<0.05);治疗后试验组各免疫指标较对照组改善明显,尤其是CD4/CD8(比值)、补体(C3)、外周血白细胞及中性粒细胞水平有显著性意义(P<0.01);化疗带来不良反应发生率试验组较对照组显著降低(29%比71%,P<0.01)。结论:甘露聚糖肽序贯治疗与放化疗联合应用,治疗晚期胃癌,可显著提高患者生存质量,全面增强患者免疫功能,减低放化疗带来的副作用,效果优于胸腺肽序贯治疗。
Objective：To observe the effect of sequential therapy of mannatide combined with chemotherapy to treat gastric cancer.Methods：102 hospitalized patients with gastric cancer were randomized into treatment group and control group.Each group received conventional therapy（DCF chemotherapy）.The treatment group was given the sequential therapy of mannatide.The control group received the sequential therapy of thymosin.Outcome measures：（1） Quality of life（QOL） ： To evaluate the QOL of median survival time and one year after the treatment.（2） Immunological parameters： CD4,CD8,CD4/CD8,peripheral blood leukocytes,antibody（IgA,IgG,IgM）,alexin（C3）,neutrophil.（3） Adverse reactions： chemoradiotherapy common adverse reactions such as nausea and vomiting.Results：Compared with the control group,the KPS and the median survival time of the treatment group were significantly different（P0.05） after a year of treatment,and the immune index of the treatment group were significant improved;especially the ratio of CD4/CD8,the count of complement（C3）,peripheral leukocyte and the neutrophilic granulocyte were significantly different（P0.01）.The incidence rate of adverse chemotherapy reactions of treatment group were significant decreased contrast with the control group（29% to 71%,P0.01）.Conclusion：The application of sequential therapy of mannatide combined with chemotherapy significantly improved the patients’ life quality;enhanced the immunologic function comprehensively;reduced the incidence rate of adverse chemotherapy reactions;and had a better effect than the sequential therapy of thymosin.
出处
《中国医药导刊》
2013年第3期463-464,共2页
Chinese Journal of Medicinal Guide
关键词
甘露聚糖肽
序贯疗法
化疗
胃癌
Mannatide
Sequential therapy
Chemotherapy
Gastric cancer
