摘要
目的 探讨高氟饮水对小鼠脑功能的影响。方法 对饮加氟离子浓度 10 0、5 0、10 mg/ L水 6个月的小鼠 ,通过行为毒理学实验 (穿梭箱试验 )判断其学习和记忆功能 ,并对其脑组织胆碱酯酶 (Ch E)活力进行测定。结果 饮高氟水的小鼠学习和记忆能力显著落后于对照组 ;高氟组小鼠脑组织 Ch E活力显著高于对照组。结论 高氟饮水对小鼠脑功能有显著的影响 ,氟对中枢神经系统具有毒性作用。
Objective To study the effects of high fluoride concentration in drinking water on the cerebral functions of mice.Methods The abilities of learning and memory of high-fluoride exposed and control groups of mice were measured by behavior-toxicological test (Shuttle box Test) and the cholinesterase (ChE) activity in brain tissue homogeate of the mice was determined.Results The abilities of learning and memory of high-fluoride exposed groups were significantly lower than that of the control group,while the brain ChE activities of high-fluoride exposed groups were significantly higher.Conclusions High fluoride concentration in drinking water could decrease the cerebral functions of mice.Fluoride is a neurotoxicant.
出处
《中国地方病学杂志》
CAS
CSCD
2000年第4期262-263,共2页
Chinese Jouranl of Endemiology
基金
天津医科大学青年基金!资助 ( 1998)
关键词
胆碱酯酶
饮水型氟中毒
脑功能
小鼠
Fluoride
Drinking water
Cerebral function
Cholinesterase
