摘要
目的 :侵及浆膜的胃癌腹膜种植复发是外科治疗失败的重要因素之一。本文探讨术后腹腔内化疗在防治腹膜复发的作用。方法 :对我院 3年间行手术治疗的胃癌 40 4例中癌肿侵及浆膜又无种植灶及远处转移的 41例术后行腹腔内化疗 (治疗组 )其临床效果与同期未行腹腔内化疗 (对照组 )进行对照观察。结果 :治疗组一、三、五年生存率为 89% ,73 % ,5 7% ,对照组为 83 % ,6 1%和 39% ,五年存活率P <0 0 5。结论 :腹腔内化疗因其腹腔内药物浓度高 ,剂量大 ,毒副作用小 。
Purpose:The majority of gastric carcinoma patients with serosal invasion die of peritoneal recurrence,even when a curative gastrectomy is performed. In an attempt to prevent peritoneal recurrence, intraperitoneal chemotherpy (IC) was used.Methods:Between 1991 and 1994,404 gastric carcinoma patients were treated in Tianjin Cancer Center., 41 cases underwent IC, and 40 were not. All of them were cases in whom the tumor had penetrated the serosa, but no implantation or distant metastasis.Results:The 1,3,5 year survival rates for the IC+IV group was 98%,73%,57% respectively, whereas those for the control group were 85%, 61%, and 39%.Conclusions:Intraperitoneal chemotherapy (IC) presents a more favorable route. It had the desired effect in preventing peritoneal recurrence in gastric carcinoma with serosal invasion.
出处
《中国癌症杂志》
CAS
CSCD
2000年第3期225-226,共2页
China Oncology
关键词
腹膜种植
进展期胃肿瘤
腹腔内化疗
复发
gastric carcinoma, surgery, intraperitoneal chemotherapy, peritoneal recurrence
