期刊文献+

肥胖发病机制及其治疗靶点 被引量:9

Obesity Pathogenesis and Therapeutic Target
原文传递
导出
摘要 人体摄入的食物提供的能量用来维持各种生理和体力活动的正常进行。在生理状态下,能量代谢保持动态平衡,即摄入能量=消耗能量+贮存能量。当由于某种原因打破这一平衡使能量的摄入大于消耗时,机体储能的主要器官--脂肪组织内脂肪(主要为甘油三酯)堆积,体重超过标准体重20%以上者,称为肥胖。随着社会经济的发展和人民生活水平的提高,全球范围内超重/肥胖率急剧增加。肥胖与高甘油三酯血症、高血压、糖尿病在发病机理上密切相关,这些慢性疾病相互影响并常在同一个体聚集存在,肥胖引起的这种交互紊乱更是诱发和加重心脑血管疾病的重要危险因素。因此,研究和分析与肥胖相关的因素及相互关系,有助于肥胖的预防和治疗。 Human intake of food energy is used to maintain the physiological and physical activity of normal.Under physiological conditions,energy metabolism maintains dynamic balance,namely the energy intake equal energy consumption and energy storage.When there is for some reason to break the balance,the energy intake is more than consumption,and the energy storage of major organs-within adipose tissue fat(triglyceride accumulation mainly).Weighing more than the standard weight of more than 20% persons,known as obesity.With the development of social economy and the improvement of people’s living standard,globally overweight / obesity rate increased dramatically.Obesity and hypertriglyceridemia,hypertension,diabetes in the pathogenesis of closely related,these chronic diseases affect each other and often occur in the same individual aggregation.his interaction disorder caused by obesity becomes important risk factor which induce and aggravate cardiovascular disease.Therefore,study and analysis of obesity related factors and their mutual relations is contribute to obesity prevention and treatment.
出处 《现代生物医学进展》 CAS 2013年第10期1997-2000,1961,共5页 Progress in Modern Biomedicine
关键词 肥胖 TG Obesity TG
  • 相关文献

参考文献34

  • 1Konturek PC, Konturek JW, Czesnikiewicz-Guzik M, et al. Neurohormonal control of food intake: basic mechanisms and clinical implications[J].J Physiol Pharmacol, 2005,56(Suppl 6):5-25.
  • 2Perboni S, Inui A. Appetite and gastrointestinal motility: role of ghrelin-family peptides[J].Clin Nutr, 2010, 29(2):227-234.
  • 3孔悦,张冰,刘小青,李慧.高甘油三酯高血糖血症大鼠脂糖代谢相关酶活性变化的实验研究[J].中国现代医学杂志,2006,16(23):3542-3545. 被引量:6
  • 4Chan MY, Zhao Y, Heng CK. Sequential responses to high-fat and high-calorie feeding in an obese mouse model [J]. Obesity (Silver Spring), 2008, 16(5):972-978.
  • 5Klaus S. Increasing the protein: carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice[J]. J Nutr,2005 Aug, 135(8): 1854-1858.
  • 6Donovan M J, Paulino G, Raybould HE. Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity [J]. Brain Res, 2009, 1248:136-140.
  • 7Goto M, Arima H, Watanabe M,et al. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures [J]. Endocrinology, 2006, 147 (11):5102-5109.
  • 8Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrclin action in the brain con-'ols adipocyte metabolism[J]. J Clin Invest, 2006, 16 (7):1983-1993.
  • 9Kim MS, Yoon CY, Jang PG, et al. The mitogenic and antiapoptotic actions ofghrelin in 3T3-L1 adipocytes [J]. Mol Endocrinol, 2004,18 (9):2291-2301.
  • 10Solomon A, De Fanti BA, Marunez JA. Peripheral ghrelin interacts with orexin neurons in glucostatic signaling[J]. Regul Pept, 2007 Dec 4, 144(1-3):17-24.

二级参考文献82

共引文献21

同被引文献89

  • 1孙涛,夏世金,张伟,郑松柏.炎性反应与衰老[J].实用老年医学,2013,27(1):79-82. 被引量:6
  • 2沈通彦,李军汉,黄雷,汤薇.运动减肥的生物学机制[J].中国组织工程研究与临床康复,2007,11(17):3415-3418. 被引量:18
  • 3杜敏联.中枢性(真性)性早熟诊治指南[J].中华儿科杂志,2007,45(6):426-427. 被引量:288
  • 4沈晓明,王卫平.儿科学[M].北京:人民卫生出版社,2007:243.
  • 5DeWire SM, Ahn S, Leikowitz RJ, et al. β -arrestins and cell signa- ling [J]. Annual Review of Physiology, 2007, 69 (2) : 483 -510.
  • 6Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insu- lin resistance in humans and their potential links with mitochondrial dysfunction [J]. Diabetes, 2006, 55 (Suppl 2) : S9-S15.
  • 7Lan Ma, Gang Pei. β - arrestin signaling and regulation of transcrip- tion [J]. Joumal ofCellScience, 2007, 120: 213-218.
  • 8Luan B, Zhao J, Wu H, et al. Deficiency of a beta - arrestin - 2 signal complex contributes to insulin resistance [ J ]. Nature, 2009, 457 (7233): 1146-1149.
  • 9Rosenfield RL, Lipton RB, Drum ML. The larche, pubarche, and menarche attainment in children with normal and elevated body mass index [ J ]. Pediatrics, 2009, 123 ( 1 ) : 84 - 88.
  • 10Domine F, Parent AS, Rasier G, et al. Assessment and mechanism of variations in pubertal timing in internationally adopted children: a developmental hypothesis [ J ]. Eur J Edocrinol, 2006, 155 : S17 - $25.

引证文献9

二级引证文献54

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部