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乳腺癌骨转移预后相关因素分析 被引量:5

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摘要 目的分析乳腺癌术后骨转移患者的预后相关因素。方法收集2001年12月~2006年12月天津医科大学附属肿瘤医院收治的乳腺癌术后首次发生远处转移且为骨转移的患者376例,回顾性分析其临床病理资料,并进行单因素和多因素逐步回归性分析。结果本组死亡260例,中位生存时间为33.0个月。单因素分析显示,肿瘤大小、病理类型、组织学分级、分子分型、乳腺癌术后是否规范化疗以及是否相继出现内脏转移与骨转移预后有关(P均<0.05);多因素分析显示,肿瘤分子分型、组织学分级、术后是否规范化疗和相继有无内脏转移与骨转移后预后有关(P均<0.05)。结论分子分型差、肿瘤组织分级高、术后未行规范化疗以及相继出现内脏转移是骨转移预后不良的独立危险因素。
出处 《山东医药》 CAS 2013年第16期30-32,共3页 Shandong Medical Journal
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参考文献12

  • 1Weissenbacher TM, Zschage M, Janni W, et al. Muhicentric and mu|tifocal versus unifocal breast cancer: is the tumor-node-metasta- sis classification justified [ J]. Breast Cancer Res Treat, 2010,122 ( 1 ) :27-34.
  • 2Yin W, Di G, Zhou L, Lu J. Time-varying pattern of recurrence risk for Chinese breast cancer patients [ J ]. Breast Cancer Res Treat, 2009,116( 1 ) :209-210.
  • 3任留梅,卫红艳,翟琼莉.骨质疏松与乳腺癌骨转移[J].中华乳腺病杂志(电子版),2011,5(4):50-53. 被引量:5
  • 4James JJ, Evans AJ, Pinder SE, et al. Bone metastases from breast carcinoma: histopathological-radiological correlations and prognostic features [ J ]. Br J Cancer, 2003,89 (4) :660-665.
  • 5Solomayer EF, Die1 IJ, Meyberg GC, et al. Metastatic breast canc- er: clinical course, prognosis and therapy related to the first site of metastasis [ J ]. Breast Cancer Res Treat, 2000,59 ( 3 ) :271-278.
  • 6Yavas O, Hayran M, Ozisik Y. Factors affecting survival in breast cancer patients following bone metastasis [ J ]. Tumori, 2007,93 (6) :580-586.
  • 7Zhu L, Loo WT, Cheng W, et al. Possible predictive markers re- lated to micro-metastasis in breast cancer patients[ J]. Oncol Rep, 2006,15(5) :1217-1223.
  • 8Lin NU, Winer EO. Brain metastasis : the HER2 Paradigm [ J ]. Clin Cancer Res, 2007,13 ( 6 ) : 1648-165.
  • 9Selzner M, Morse MA, Vredenburgh JJ, et al. Liver metastases from breast cancer: long-term survival after curative resection [ J]. Surgery, 2000,127 ( 4 ) : 383-389.
  • 10Chung CT, Carlson RW. Carlson goals and objectives in the man- agemen of metastatic breast cancer [ J ]. Oneologist, 2003,8 ( 6 ) : 514-520.

二级参考文献26

  • 1张红英,郭德华,封耀辉.乳腺癌骨转移疼痛患者的生活质量与心理干预效应[J].中国临床康复,2004,8(23):4680-4681. 被引量:9
  • 2Claire B. POLLOCK,Kathleen KELLY.Mechanisms of cancer metastasis to the bone[J].Cell Research,2005,15(1):57-62. 被引量:54
  • 3李永强,胡晓桦.唑来磷酸治疗癌性骨痛临床分析[J].广西医学,2005,27(9):1353-1355. 被引量:9
  • 4孙燕.内科肿瘤学[M].北京:人民卫生出版社,1999.88.
  • 5徐建国.疼痛药物治疗学[M].北京:人民卫生出版社,2007:264-275.
  • 6Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev, 2001, 27:165-176.
  • 7Johnson JR, Williams G, Pazdur R, et al. End points and United States Food and Drug Administration approval of oncology drugs. J Clin Oncol, 2003, 21 : 1404-1411.
  • 8Kinnane N. Burden of bone disease. Eur J Oncol Nuts, 2007, 11 Suppl 2 : S28-31.
  • 9Eubank WB, Mankoff DA. Evolving role of positron emission tomography in breast cancer imaging. Semin Nucl Med, 2005, 35:84-99.
  • 10Chow E, Harris K, Fan G, et al. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol, 2007, 25: 1423-1436.

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