摘要
选取中国市场上30个国内外卷烟样品,进行深度抽吸模式下41种化学成分的分析测试和全烟气的Ames试验。结果表明:①在10%S9的活化系统下,各类型卷烟均有剂量组对TA98的回复突变菌落比值(MR)大于2.0,表现出致突变作用;②国产烤烟型卷烟对TA98的致突变作用小于进口混合型卷烟,而且差异有统计学意义;③各类型卷烟的单位焦油比活性差异无统计学意义;④具有遗传毒性的有害成分可能影响新鲜卷烟烟气的致突变作用。
Thirty cigarette brands available in market were sampled and 41 chemical components in cigarette smoke were analyzed under intensive smoking regime, and whole smoke Ames tests were conducted. The results indicated that： l） All types of cigarette showed mutagenicity on TA98 with mutation ratios （MR values） over 2.0 in 10% S9 activation system at certain dosages; 2） The mutagenicity of domestic Virginia type cigarettes was lower than that of imported blended type cigarettes, and their difference was statistically significant; 3） Between cigarette types, the difference of specific activity per unit tar was of no significance; 4） The yields of genetoxic harmful components might affect the mutagenicity of fresh cigarette smoke.
出处
《烟草科技》
EI
CAS
北大核心
2013年第5期46-50,共5页
Tobacco Science & Technology
基金
中华人民共和国科学技术部项目"食品中热反应伴生危害物毒理学检测及风险评估关键技术研究"(2012BAK01B03)
国家烟草专卖局标准项目"卷烟全烟气暴露的体外毒理学测试方法"(2011B056)
国家自然科学基金项目"卷烟主流烟气和侧流烟气中颗粒物的尺度
化学组成与生物毒性研究"(21007094)
关键词
卷烟
全烟气
致突变作用
Cigarette
Whole cigarette smoke
Mutagenic effect
