摘要
研究了机械化学条件下乙酰乙酸乙酯与查尔酮及氮杂查尔酮的Michael加成反应。用该方法进行的反应不需要任何有机溶剂,仅10%当量的K2CO3就能使反应有效进行。在绝大多数情况下,通常的副反应被成功避免,因而产率较高,相应的Michael加成产物几乎能定量得到。对于加成产物中含有的一对非对映异构体(anti和syn)通过1H-NMR进行了归属指认。另外考察了其他催化剂对反应的影响。
Michael addition reactions of ethyl acetoacetate with chalcones and azachaleones were investigated under mechanochemical conditions. This protocol didn＇t require the use of any organic solvent during the reaction process and only 10% molar equivalent of K2 CO3 was enough to promote the reaction efficiently. In most cases, conventional side reactions were avoided and thus excellent yields were achieved;that was, almost all the Michael adducts could be obtained quantitatively. The desired Michael adducts consisting of two diastereoisomers anti and syn were determined and assigned by 1 H NMR analysis. And the influence of other catalysts on this Michael reaction was studied.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2013年第5期742-747,共6页
Chemical Research and Application
基金
国家自然科学基金项目(20902002
21242013)资助
