摘要
目的探讨降钙素原(PCT)、联合C反应蛋白(CRP)、白细胞(WBC)检测在新生儿感染性肺炎(NIP)中的临床价值,为新生儿感染性肺炎的早期诊断和治疗提供依据。方法选择医院住院治疗的236名新生儿感染性肺炎患者为研究组,同期出生的236名健康新生儿为对照组,分析两组新生儿的PCT、CRP和WBC的变化。结果联合检测对研究组、细菌感染组、混合感染组与其他组的灵敏度为80.5%、95.6%、85.6%、10.0%;特异度分别为72.0%、88.6%、70.3%、60.0%;联合检测灵敏度与特异度分别为80.5%与72.0%;PCT和CRP在细菌性感染组和混合感染中显著上升(P<0.05);治疗前后均有显著性改变(P<0.05);WBC仅在细菌性感染组显著上升(P<0.05),改变幅度<PCT和CRP,但治疗前后仍有显著性改变(P<0.05);未在其他感染组观察到3个指标的显著改变。结论 PCT较CRP和WBC灵敏度高,PCT联合CRP、WBC检测能有效执行对细菌性/混合性肺炎的鉴别诊断和疗效监测,是新生儿肺炎的合理血清学感染指标组合模式。
OBJECTIVE To explore clinical value of procalcitonin-C reactive protein-white blood cell joint test in the neonates with infectious pneumonia so as to provide evidence for early diagnosis and treatment of the infectious pneumonia.METHODS A total of 236 cases of neonates with infectious pneumonia,who were treated in the hospital,were selected as the research group and 236 healthy newborn babies as the control group,the changes of PCT,CRP and WBC were compared between the two groups of neonates.RESULTS The sensitivity of the joint test to the research group,the bacterial infection group,the mixed infections group,and the other groups were 80.5%,95.6%,85.6%,and 10.0%,respectively;the specificity were 72.0%,88.6%,70.3%,and 60.0%,respectively;the sensitivity of the joint test was 80.5%,the specificity 72.0%;the levels of PCT and CRP were significantly elevated in the bacterial infection group and the mixed infections group（P〈0.05）,showing a significant difference between before and after the treatment（P〈0.05）;the level of WBC was elevated only in the bacterial infection group（P〈0.05）,changing less significantly than the PCT and CRP,but with a significant difference between before and after the treatment（P〈0.05）;no significant change of the three indicators were observed in other infection group.CONCLUSION PCT is more sensitive and reliable than CRP and WBC in the early diagnosis of infectious pneumonia in the newborns,and the procalcitonin-C reactive protein-white blood cell joint test can help differentiate between the bacterial pneumonia and the mixed pneumonia and monitor the efficacy,which is a reasonable indicator joint pattern of the serology test for the neonates with pneumonia.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2515-2517,共3页
Chinese Journal of Nosocomiology
关键词
降钙素原
C反应蛋白
白细胞
新生儿
感染性肺炎
Procalcitonin
C-reactive protein
White blood cell
Neonate
Infectious pneumonia
