摘要
[目的]观察心脉通胶囊联合福辛普利治疗原发性高血压病疗效。[方法]使用随机平行对照方法,将116例住院及门诊患者按就诊顺序编号随机分为两组,对照组58例福辛普利片10mg/次,1次/d,早晨口服。治疗组58例心脉通胶囊口服,3粒/次,3次/d;西药治疗同对照组。连续治疗6周为1疗程。观测临床症状、血压、血清甘油三酯、总胆固醇、血常规、尿常规、肝肾功能、心电图、电解质、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组显效26例,有效29例,无效3例,总有效率94.80%;对照组显效17例,有效29例,无效12例,总有效率79.70%;治疗组临床疗效优于对照组(P<0.05)。血压两组均明显下降(P<0.01),治疗组优于对照组(P<0.05);甘油三脂、总胆固醇治疗组下降明显(P<0.05),对照组不明显(P>0.05);甘油三脂、总胆固醇改善治疗组优于对照组(P<0.05,P<0.01);不良反应发生率治疗组3.40%低于对照组13.80%(P<0.05)。[结论]心脉通胶囊联合福辛普利治疗原发性高血压较单用福辛普利降压疗效更显著,能显著改善患者血脂代谢,无明显毒副作用。
[ Objective ] To investigate therapeutic effect of Xinmaitong capsule combined with Fosinopril on primary hypertension. [Methods] Based on randomized parallel controlled study, a total of 116 outpatients and inpatients are enrolled and randomly divided into study and control group according to their visit sequence, with 58 cases in each. Subjects in control group are given fosinopril 10rag once per day orally in morning, subjects in study group are administered Xinmaitong capsule 3 pills once three times per day, together with fosinopril treatment as same as control group, the therapy lasts for 6 weeks. Clinical symptoms, blood pressure, serum triglycerides, total cholesterol, blood and urine routine tests, hepatic and renal functions, electro- cardiogram, electrolyte and adverse effects are assessed pre and post therapy. [ Result ] 26 and 29 cases partly respond and respond to the therapy, 3 cases dont respond in study group, total effective rate is 94.80% , 17 and 29 cases partly respond and respond to the therapy, 12 cases dont respond in control group, total effective rate is 79.70% , therapeutic effect in study group is better compared to control group. Blood pressure is decreased greatly pre and post treatment in study group compared to control （ P 〈 0.05 ）. Serum triglyceride and total Cholesterol levels are lowered after the treatment in study group （P 〈 O. 05, P 〈 0.01 ） , while, they arent decreased significantly in control group （P 〉 0.05）, incidence of adverse effect in study group is 3. 40% , significantly lower than 13. 80% in control group （ P 〈 0. 05 ）. [ Conclusion ] Xinmaitong Capsule combind with Fosinopril is more effective than Fosinopril alone to treat primary hypertension, and can improve lipid metabolic disorder and without severe side effects.
出处
《实用中医内科杂志》
2013年第2期11-13,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
原发性高血压
心脉通胶囊
福辛普利
甘油三脂
总胆固醇
中西医结合治疗
随机平行对照研究
Essential hypertension
Xinmaitong Capsule
Fosinopril
Triglyceride
Total Cholesterol, Con- bined treatment of Traditional Chinese Medicine and Western Medicine
Random parallel control study
