摘要
目的:探讨白介素-6(IL-6)、白介素-8(IL-8)及超敏C-反应蛋白(hsCRP)在不稳定型心绞痛(un-stable angina pectoris,UAP)患者血清中的表达及意义。方法:选取我院收治的UAP患者128例设为观察组,采用酶联免疫吸附法检测血清IL-6、IL-8;胶乳增强免疫比浊法测定患者血清hsCRP,并设同期体检正常者为对照组,同法检测IL-6、IL-8和hsCRP,进行对比分析。结果:观察组IL-6、IL-8、hsCRP水平较对照组明显增高,差异具有统计学意义(P<0.05);且观察组UAP危险分级增高,IL-6、IL-8、hsCRP水平亦增高,IL-6、IL-8、hsCRP水平与UAP分级呈明显正相关。结论:IL-6、IL-8、hsCRP在UAP患者血清中呈高表达状态,与冠脉病变的发病存在相关性。
Objective. To explore the expression and significance of interleukin-6 （IL-6）, interleu- kin-8 （IL-8）, high sensitive C-creative protein （hsCRP） in the serum of patients with unstable angina pec- toffs （UAP）. Methods. A total of 128 UAP patients who were admitted from March, 2009 to September, 2011 were enrolled in the study and served as the observation group. The individuals with the normal physical examination at the same stage served as the control group. The enzyme linked immunosorbent as- say was used to detect the serum IL-6 and IL-8. The determination of the serum hsCRP was by latex en- hanced immunoturbidimetric assay. Results： The levels of IL-6, IL-8 and hsCRP in the observation group was significantly increased when compared to the control group （P〈0.05）. Moreover, UAP risk classifi- cation, the levels of IL-6, IL-8 and hsCRP in the observation group were enhanced. The levels of IL-6, IL-8 and hsCRP were positively correlated to the UAP classification. Conclusions. IL-6, IL-8 and hsCRP are highly expressed in the serum of patients with UAP and are correlated with the attack of coronary artery disease.
出处
《海南医学院学报》
CAS
2013年第7期927-929,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210709)~~
