摘要
目的分析紫杉醇联合顺铂对晚期食管癌的疗效及副作用。方法分析2009年1月-2012年9月该科收治32例晚期食管癌患者,使用紫杉醇(175 mg·m-2),静脉滴注第1天;顺铂30 mg,静脉滴注第1～4天,21 d为一疗程。结果 32例晚期食管癌患者,CR 2例,PR 14例,SD 11例,总体有效率[(CR+PR)/患者总数×100%]43.75%,中位生存期11.9月,副反应主要为骨髓抑制,Ⅳ度白细胞减少发生率12.5%,Ⅱ～Ⅲ度白细胞减少发生率43.75%,出现粒细胞缺乏性发热致死亡1例。结论紫杉醇联合顺铂对晚期食管癌疗效明显,副作用主要是骨髓抑制,是临床可以选择的化疗方案。
Objective To investigate response rate, survival and toxicities ot paclitaxel combined with clsplatin in tlae treatment ot advanced esophageal cancer. Methods Thirty-two cases with advanced esophageal cancer were treated with paclitaxel 175 mg . m-2 ivgtt dl, and eisplatin 30 mg ivgtt dl-4. Treatment was repeated every 21 days. Results Of all Thirty-two patients, major objective responses were observed in 16 patients （43.75%）, including 2 complete responses and 14 partial responses. The median actuarial survival was 11.9 months. The most common nonhematologic toxicity was alopecia. Grade 4 neutropenia was observed in 12.5% of the patients. Conclusion The combination of paclitaxel and cisplatin is safe and effective for the treatment of advanced esophageal cancer.
出处
《安徽医药》
CAS
2013年第5期854-855,共2页
Anhui Medical and Pharmaceutical Journal
关键词
食管肿瘤
紫杉醇
顺铂
esophageal neoplasm
paclitaxel
cisplatin
