摘要
回顾性分析717例2型糖尿病患者临床资料，根据患者血清C肽水平将其分为正常C肽组（〉1.1 ng/ml）与低C肽组（〈1.1 ng/ml）。结果显示，正常C肽组HbA1C、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及总胆固醇（TC）水平显著低于低C肽组（P〈0.05或P〈0.01）；正常C肽组糖尿病视网膜病变发生率显著低于低C肽组（P〈0.05）；冠心病的发生率显著高于低C肽组（P〈0.01）；Pearson相关性分析显示血清C肽与HbA1C、LDL-C、TC、HDL-C呈负相关（P〈0.05），与冠心病发病呈正相关（P〈0.01）。Logistic回归分析显示C肽是冠心病的独立影响因素。
The clinical data of 717 patients with type 2 diabetes were retrospectively analyzed. These patients were divided into normal C-peptide group（〉1.1 ng/ml） and low C-peptide group（〈1.1 ng/ml） based on C-peptide levels. The results showed that HbA1C, high density lipoprotein-cholesterol （HDL-C）, low density lipoprotein-cholesterol （LDL-C）, and total cholesterol （TC） levels in normal C-peptide group were lower than those in low C-peptide group （P〈0.05 or P〈0.01）. The incidence of diabetic retinopathy （P〈0.05） was lower and that of coronary arterial disease （P〈0.01） was higher in normal C-peptide group as compared with low C-peptide group. Serum C-peptide level was negatively correlated with HbA1C, HDL-C, LDL-C, and TC （P〈0.05）, and positively correlated with coronary arterial disease. C-peptide was the independent influencing factor of coronary heart disease shown by the logistic regression.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第5期380-382,共3页
Chinese Journal of Endocrinology and Metabolism
基金
江苏省自然科学基金（BK2010121）
关键词
血清C肽
糖尿病
2型
血糖控制
糖尿病并发症
Serum C-peptide
Diabetes mellitus, type 2
Blood glucose control
Diabetic complications
