摘要
目的探讨急性脑梗死患者氧化型低密度脂蛋白(ox-LDL)水平的特点及ox-LDL致脑梗死的发病机制,评价普罗布考对ox-LDL及血管功能的改善作用。方法 120例急性脑梗死患者根据是否合并高血压分为血压正常组和合并高血压组各60例,再将2个病例组分别随机分为干预组和未干预组,每组30例,干预组患者在常规治疗的基础上加用普罗布考治疗,所有患者分别于治疗前,治疗后2周、12周检测ox-LDL、内皮型一氧化氮合酶(eNOS)及NO水平。结果脑梗死合并高血压组的ox-LDL高于正常血压组,eNOS、NO水平低于正常血压组。对于脑梗死正常血压患者,普罗布考干预治疗12周后,TC、HDL、ox-LDL水平降低,eNOS升高(P<0.05)。对于脑梗死合并高血压患者,普罗布考干预治疗12周后,TC、TG、LDL、ox-LDL水平降低,eNOS、NO升高(P<0.05)。结论普罗布考除具有调脂作用外,还可降低ox-LDL水平,改善血管内皮功能,稳定斑块,有利于防止发生动脉粥样硬化。
Objective To investigate the changes of oxidized low-density lipoproteins （ox-LDL） in patients with acute cerebral infarction, and to evaluate the effect of the supplement therapy with probucol on the plasma concentrations of ox-LDL. Methods One hundred and twenty patients with acute cerebral infarction were divided into normal blood pressure group （n=60） and hypertension group （n=60） according to whether the cerebral infarction combinated with hypertension. The two groups were randomly divided into two subgroups, intervention group （n=30） and nonintervention group （n=30） respective- ly. Patients were treated with probucol and routine treatment for 12 weeks in intervention group. The levels of ox-LDL, nitric oxide （NO） and endothelial nitric oxide synthase （eNOS） were detected before treatment and 2-week and 12-week after treat- ment in all groups of patients. Results The level of ox-LDL was significantly higher, but the serum levels of eNOS and NO were significantly lower, in patients with acute cerebral infarction conbinated with hypertension than those in patients with acute cerebral infarction and normal blood pressure （P 〈 0.05）. The levels of total cholesterol （TC）, high density lipoprotein （HDL） and ox-LDL were significantly increased after supplement therapy with probucol for 12 weeks in patients with acute ce- rebral infarction and normal blood pressure, and the level of eNOS was significantly increased （P 〈 0.05）. For hypertensive pa- tients with acute cerebral infarction, the levels of TC, triglycerides （TG）, LDL and ox-LDL were significantly decreased, and levels of eNOS and NO were significantly increased after supplement therapy with probucol forl2 weeks （P 〈 0.05）. Conclu- sion The present study demonstrated that probucol can reduce the level of ox-LDL, improve endothelial function, stabilize plaque and help prevent atherosclerosis in patients with acute cerebral infarcton.
出处
《天津医药》
CAS
北大核心
2013年第5期412-415,共4页
Tianjin Medical Journal
基金
天津市高等学校科技发展基金计划项目(项目编号:20080123)
高等学校博士学科点专项科研基金(项目编号:200800620010)
天津医科大学第二医院科研基金(项目编号:2008eyzdxk07)
