摘要
目的探讨正常形态前向运动精子总数这一新的精液参数与体外受精（IVF）结局之间的关系。方法分析首次接受IVF新鲜移植周期治疗的1，972对夫妇取卵前三个月内的平均正常形态前向运动精子总数、MII卯受精率、多原核（PN）率、卵裂率、优胚率、临床妊娠率等数据，观察正常形态前向运动精子总数对IVF受精率、多PN率、卯裂率、优胚率、临床妊娠率的影响。结果不同水平正常形态前向运动精子总数组间多PN率、卵裂率、优胚率、临床妊娠率无统计学差异，但不同水平正常形态前向运动精子总数组间受精率有明显统计学差异（P〈0．05），随着正常形态前向运动精子总数的增加受精率明显增加，当正常形态前向运动精子总数小于1．8×10^6／ml时，IVF受精率小于30％或50％的异常受精患者的比例可达13．80％或26．10％。结论正常形态前向运动精子总数可作为一个独立的精液质量评价指标指导辅助生育治疗。对于正常形态前向运动精子总数太少的患者可考虑选择行卵胞浆内单精子注射（ICSI）或Half-ICSI减少IVF受精失败。
Objective： To investigate the relationship between the total number of normal form and progressive motility sperm（TNNPS）and the outcome of in vitro fertilization（IVF）. Methods： We analyzed the data of TNNPS in 1,972 couples three months before their first IVF-ET cycle and detected the effect of TNNPS on the fertilization rate, poly-PN rate, cleavage rate, good embryo rate and pregnancy rate. Results： Among different TNNPS groups, there were no statistical differences in the poly-PN rate, cleavage rate,good embryo rate and clinical pregnancy rate, but a statistical difference was found in the fertilization rate（P〈0.05）. The fertilization rate increased significantly along with the TNNPS increased. When the TNNPS was less than 1.8 × 10^6/ml, the percentage of abnormal fertilization patient with IVF fertilization rate less than 30%（or 50%）was 13.80%（or 26.10%）. Conclusion. The TNNPS could be as an independent indicator for evaluating semen quality in assisted reproductive technology therapy. For the patients with TNNPS less than 1.8× 10^6/ml, half-ICSI or ICSI should be performed tO avoid IVF failure. Key words： Progressive motility sperm; In vitro fertilization; Clinical pregnancy rate
出处
《生殖医学杂志》
CAS
2013年第5期329-333,共5页
Journal of Reproductive Medicine
基金
广东省医学科学技术研究基金(A2009626
B2010292)
深港创新圈项目(ZYB200907090141A)资助
关键词
前向运动精子
体外受精
临床妊娠率
Progressive motility sperm
In vitro fertilization
Clinical pregnancy rate
