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N-(取代苯氧乙酰基)-3-氨基-二氢噻吩-2-酮衍生物的合成和生物活性

Synthesis and bioactivity of N-(substituted phenoxyacetyl)-3-amino-dihydrothiophene-2-one derivatives
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摘要 酰胺类化合物具有很高的药用活性,为了进一步研究酰胺衍生物的合成与性质,文中用3-氨基-二氢噻吩-2-酮盐酸盐与取代苯氧乙酸反应,得到N-(取代苯氧乙酰基)-3-氨基-二氢噻吩-2-酮衍生物。产物结构经IR、1H NMR和元素确证。对5种病原菌的抑菌活性进行了生物活性测试。合成中采用三氯氧磷为缩合试剂,采用一锅反应,简便易行,缩合试剂价廉易得、反应收率高,产物纯度较高,为此类新化合物的合成和筛选提供了依据。 The amide compounds have high pharmaceutical activity. To further study the synthesis and properties of the amide compounds, N-( substituted phenoxyacetyl)-3-amino-dihydrothiophene-2-one derivatives were synthesized by the reaction of substituted phenoxyacetic acid with 3-amino-dihydrothiophene-2-one hydrochloride. The structures were confirmed by IR, 1HNMR and elemental analysis. The antifungal activity of 5 pathogens were tested. Phosphorus oxychloride was used as the condensation reagent in synthesis. The method has advantages with one-pot synthesis, simple and easy operation, cheap and easily-obtained raw material, high yield and high purity. The results provide the basis for synthetizing and screening new compounds.
出处 《化学工程》 CAS CSCD 北大核心 2013年第5期6-9,共4页 Chemical Engineering(China)
基金 国家自然科学基金资助项目(2107314) 陕西省教育厅自然科学专项资助项目(2013JK0666)
关键词 3-氨基-二氢噻吩-2-酮 酰胺 苯甲酸 噻吩酮 合成 生物活性 3-amino-dihydrothiophene-2-one amide benzoic acid thienone synthesis bioactivity
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  • 1崔学桂,孙宏建,刘德信,李晓燕,李淑兰.邻香兰素甘氨酸三吡啶合Ni(Ⅱ)的合成、性质、晶体结构及热分解动力学[J].化学学报,1993,51(4):346-351. 被引量:13
  • 2李正名.农药化学现状和发展动向[J].应用化学,1993,10(5):14-21. 被引量:23
  • 3柳翠英,郭秀英.5-硝基,N(2-羟基乙基)水杨醛亚胺Schiff碱的合成[J].化学试剂,1994,16(6):368-368. 被引量:19
  • 4[1]Schmeling B von, Kulka M..Systemic fungicidal activity of 1,4-oxathiin derivation. Sceince NO.3722,1966,152:659-660.
  • 5[2]Leroux P. Recent developments in the mode of action of fungicides.Pestic. Sci., 1996,47:91-197.
  • 6[3]Snel M., von Schmeling B., Edgington LV. Fungitoxicity and structure activity relationships of some oxathiin and thiazole derivatives. Phytopathology, 1970,60:1164-1 169.
  • 7[4]Kulka M., Schmeling B von. Carboxin fungicides and related compounds. In: Lvr, H. (Ed.): Modem Selective Fungicides:properties. application, mechanism of action. 2ed. Edu. Gustav Fisher Veriag, Jena, Germany, 1995.
  • 8[5]Pommer EH. Girgensohn B, Konig KH, et al. Development of new svstemic fungicides with carboxailide structure. Kemia-Kemi, 1974,1:617-618.
  • 9[6]O'Relly P, Kolayahi S, Yamane S, et al. A novel fungicide with broad-speetrum diseases control. Brighton Crop Prot. Conf Pest and Diseases, 1992,427-434.
  • 10[7]Schewe T., Lyr H.. Mechanism of action of carboxin fungicides and related compound.In: Lyr, H(Ed. ): Modem Selecvtive Fungicides:properties, application, machanism of action, 2ed. Edu. Gustav Fisher Verlag, Jena. Germany, 1995.

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