摘要
为了探讨重组人生长激素治疗大面积 烧伤的有效性和安全性，将伤后24小 时内入院的大面积烧伤患者随机分为治疗组和对照组，每组各10例。治疗组从第3天开始每 日给予重组人生长激素0.5 IU/kg皮下注射，持续14天，对照组则每 日给予安慰剂。此外，两组患者Ⅲ度创面均早期切痂植皮，Ⅱ度创面保守治疗，其余治疗基 本相同，直至创面痊愈。治疗期间定期检测患者的血红蛋白、血清白蛋白、代谢率、深Ⅱ度 创面及供皮区的愈合时间、体重变化、住院时间和感染发生情况。结果：治疗组血红蛋白、 血清白蛋白和代谢率较对照组增高，深Ⅱ度创面和供皮区愈合时间及住院时间较对照组缩短 ，体重下降减少，感染发生减少。治疗组有2例曾出现持续性高血糖，经短暂使用胰岛素后 恢复正常，其余未见明显副作用。上述结果表明，重组人生长激素对大面积烧伤患者有明显 的治疗作用，并且是安全的。
In order to investigate the effectiveness and safety of recomb inant hu man growth hormone(rhGH) treatment for severe burn injury, we designed a randomi zed prospective study.The patients in rhGH group were given rhGH in a dose of 0 .5 IU/(kg穌) subcutaneously between days 3-17 post-burn. Indices about protei n me tabolism, wound healing, hepatic and renal function and blood were measured regu larly. Patients were monitored until their wound healed sufficiently so that the y could be discharged for rehabilitation. The results showed: all patients survi ved; the rhGH group had less weight loss，increased level of serum albumin and s horter healing time of deep partial-thickness burn and donor site. The hospital stay time decreased from the control value of 45±17 days to 37±12 days for rhG H treated patients, i.e. a significant improvement. Resistant hyperglycemia was present in 2 patients in the rhGH group and disappeared after transient insulin administration. This study demonstrates that rhGH treatment for severe burn inju ry has obvious beneficial effects with slight side-effects.
出处
《华西医科大学学报》
CSCD
2000年第3期399-401,共3页
Journal of West China University of Medical Sciences
