摘要
目的探讨连续性肾替代治疗(CRRT)时机对重症急性胰腺炎(SAP)患者细胞因子及预后的影响。方法比较20例SAP发病后48 h内行CRRT(早期组)患者和16例48 h以后行CRRT(晚期组)患者白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子-(TNF-)水平。结果治疗前两组患者IL-1、IL-6、TNF-水平差异均无统计学意义(均>0.05)。晚期组第2天IL-1、IL-6水平均高于早期组(均<0.05);第3天IL-6、TNF-水平均高于早期组(均<0.05)。结论早期CRRT能清除SAP患者IL-1、IL-6、TNF-等细胞因子,使SAP患者获得更大的临床效益。
Objective To investigate the effects of continuous renal replacement therapy （CRRT） on cytokines and prognosis in severe acute pancreatitis （SAP） patients based on different time. Methods Thirty-six SAP patients were randomly divided into two groups： early group （CRRT within 48h） of 20 patients and late group（CRRT after 48h） of 16 patients. The mortality, the levels of interleukin-1β（IL-1β）, interleukin-6 （IL-6）and tumor necrosis factor-a （TNF-a） were compared between the two gro- ups. Results The levels of IL-1β and IL-6were significantly higher in late group than those in early group on the second day （P 〈 0.05）, and the levels of IL-6 and TNF-a were significantly higher in late group than those in early group on day 3 （P 0.05）. There were no significant differences in IL-1β, IL-6 and TNF-a before treatment （P 〉 0.05）, and there were no significant differences in gender, age and APACHE II score （P 〈0.05）. Conclusions Early CRRT therapy can eliminate IL-1β, IL-6 and TNF-a in SAP patients, and CRRT may provide more clinical benefits in the early phase （within 48 h） of SAP.
出处
《现代实用医学》
2013年第4期367-368,371,共3页
Modern Practical Medicine
基金
温岭市科技局立项课题(2011wlcb0095)
