摘要
目的通过再狭窄动物模型的制作研究实验犬食管支架术后不同时间局部组织的形态学变化。方法以16只成年健康犬为实验对象 ,均分4组。采取“自体阔筋膜移植固定法”置入“Z”型自扩张金属食管支架 ,术后1、2、4、8周分批处死动物 ,取出置架部位的食管组织 ,进行大体形态、光镜、电镜等病理分析。结果术后1周 ,置架部位食管粘膜明显充血水肿 ,局部大量炎性细胞浸润 ,某些部位组织开始向管腔内生长 ;术后2周 ,食管组织增生显著 ,大部分支架结构被增生组织所覆盖 ,局部有广泛肉芽组织形成及部分纤维化 ;术后4、8周 ,增生组织已完全覆盖支架结构 ,并连接成片 ,管腔明显狭窄 ,局部出现大量的纤维结缔组织 ,炎性细胞及新生毛细血管显著减少。电镜发现 ,术后2周组织中成纤维细胞处于旺盛的增殖及分泌状态 ,术后8周可见大量纤维组织形成。结论再狭窄主要表现为肉芽组织形成及纤维化 ,炎性细胞的浸润是再狭窄形成的起始因素 ,术后4、8周随着炎性反应的减弱 ,纤维化过程渐趋稳定。
Objective Animal experiments were executed to observe the morphological changes at different periods in esophagus into which artificial stent had been placed. Methods An autodistensible stainless steel stent was placed in every esophagus of 16 adult dogs after the mode of “autogenous fascia-lata transplantation”. Every 4 dogs were killed at a time by the end of 1, 2, 4, 8 weeks. A portion of esophagus together with the stent were taken for pathology. Results Microscopically, by one week, the mucosa became highly congested and swollen, a few tissues proliferated into the stent; by two weeks greaterpart of the stent was covered, inside and outside, by patches of granulation and fibrous tissue; by four and eight weeks the stent was completely walled off byproliferated fibro-connective tissues with obvious narrowing of the lumen andreduction of inflammatory reaction. Conclusion The formation of restenoses ofthe stent is initiated by inflammatory response, which is replaced gradually bygranulations and fibrosis.
出处
《中华消化内镜杂志》
2000年第4期217-219,共3页
Chinese Journal of Digestive Endoscopy
基金
国家自然科学基金!资助(No :39670341)
