摘要
目的 探讨严重烧伤早期脑水肿MRI表现与病理改变的相关性。方法 5 2只家犬采用凝固汽油体表燃烧法制成 5 0 %TBSAⅢ度模型。应用MRI表现与病理改变对比分析法对各实验组 (对照组、单烧组、平衡液组和葡萄糖液组 )犬进行了动态观察。结果 严重烧伤早期脑水肿模型 (葡萄糖液组 )显示MRI改变的最早时间为伤后 12h ,以弥漫性脑肿胀为其表现特征。当T1 WISIR低于 10 %时 ,MRI难以发现 ;伤后2 4hT2 WISIR增高 8.2 9% ,脑灰、白质界限模糊 ,部分消失。病理学观察烧伤 6h以后毛细血管内皮细胞及血管周围星形胶质细胞终足肿胀 ;神经细胞出现空泡状现象 ;毛细血管内皮细胞 ,神经细胞及轴突呈不同程度的缺血性改变。随着观察时间的延长 ,这种改变逐渐明显 ,以伤后 2 4h表现最为显著。结论 严重烧伤早期脑水肿模型兼有血管源性和细胞毒性脑水肿的MRI及病理组织学特征。
Objective To study the correlation between MRI features and pathological changes in brain edema in the early stage of severe burn in dogs. Methods 52 mongrel dogs were inflicted with 50% TBSAⅢ burns and randomized into control, simple burn (SB), balanced salt solution (BSS) and glucose solution (GS) groups. The MRI manifestation and pathological features were observed and compared. Results The earliest appearance of brain edema was found at 12 h after burn in GS group with MRI, which showed a diffuse brain swelling. The decrease of SIR on T 1WI was not observed until it was above 10%. Signal of T 2WI increased by 8.29% at 24 h after burn. It was difficult to distinguish the gray matter from the white matter at the boundary line, even not be seen later. Histological changes of brain edema were observed as early as 6 h after burn, accompanied with swelling of endothelial cells and peri vascular astrocytes, vacuolation in neurocytes, and ischemic alterations of different degrees of capillary endothelium, neurons and axons. These changes became more marked with lapse of time. The GS group showed the most obvious consequences mentioned above at 24 h after burn. Conclusion The model of the brain edema after severe burn had the feature of both vasogenic edema and cellular edema in the MRI and pathology.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2000年第9期844-848,共5页
Journal of Third Military Medical University
基金
重庆市科技计划资助项目
