摘要
目的探讨甲基强的松龙对重症支原体肺炎患儿治疗前后的免疫指标的影响。方法对30例重症支原体肺炎患儿使用甲基强的松龙治疗前后的的疫指标进行检测,并与18例使用地塞米松治疗的患儿、18例未使用糖皮质激素治疗前后的患儿进行对照。结果治疗前三组患儿的体液免疫指标、细胞免疫指标均无显著性差异(p>0.05);治疗后,联合甲基强的松龙组患儿血清IgA、IgM、IgG指标与联合地米组无显著性差异(p>0.05),与非联合激素组IgM、IgG指标有显著性差异(p<0.05);治疗后联合甲基强的松龙组CD4+、CD4+/CD8+值比地米组、非联合激素组明显增高,差异有统计学意义(p<0.05),CD8+值明显下降,有统计学意义(p<0.05);持续发热及肺部啰音减少时间较地塞米松组、非联合激素组明显减少,差异有统计学意义(p<0.05)。结论使用甲基强的松龙治疗前后的重症支原体肺炎患儿的免疫指标有明显变化,建议及早应用,有利于缩短病程。
Objective To explore the changes of immune indexes in severe mycoplasma pneumonia children after treatment of methylprednisolone. Methods The immune indexes in 30 cases of severe myeoplasma pneumonia children before and after methylprednisolone therapy were tested, and compared with two groups： one was treated with dexamethasone thera- py, the other with non - glueoeortieoid treatment. Results No statistical difference was found in the cell - mediated immunity and humoral immunity of the three groups before therapy（p 〉 0. 05 ）. After treatment, no statistical differenee was found in IgA IgM IgG levels in combined methylprednisolone group and combined dexamethasone group（p 〉 0. 05 ）, however, the sta- tistical difference was found in IgM IgG levels in non -combined hormone group（p 〈 0. 05 ） ; after treatment, CD4 ＋ T eell, ratio of CD4＋ T cell to CD8 ＋ T cell increased signifieantly（p 〈 0. 05 ）, CD8 ＋ T cell decreased signifieantly（p 〈 0. 05 ）. Fe- ver time, disappearing time of lung rale in group with combined methylprednisolone obviouslY shortened comparing with those of group with combined dexamethasone and group with non - combined hormone, the difference was statistically significant （p 〈 0. 05 ） o Conclusion The immune indexes of severe mycoplasma pneumonia before and after treatment with methylpred- nisolone had the obvious change. Early applieation earl shorten the course of disease.
出处
《现代医院》
2013年第5期46-48,共3页
Modern Hospitals
