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大肠癌术后肝转移高危因素研究 被引量:1

Analysis of high risk factors of liver metastasis in patients with postoperative colorectal cancer
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摘要 目的筛选大肠癌根治术后发生肝转移的高危因素,并建立数学模型。方法分析168例患者5年随访资料,logistics回归明确术后肝转移的高危因素,ROC检验建立数学模型。结果全组3年和5年肝转移发生率为25.0%和33.3%,高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平,数学模型为logit(P)=-0.931+0.973×淋巴结转移+0.302×肿瘤浸润深度+0.637X组织学分级+0.042×术前肿瘤标志物水平。结论大肠癌术后肝转移的高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平,并可建立数学模型。 Objective To screen the risk factors of liver metastasis in patients with postoperative colorectal cancer and to set up a mathematic model. Methods One hundred and sixty-eight patients received radical surgery were retrospectively analyzed. Logistics model regression was used to identify the risk factors and ROC test to complete a mathematic model. Results The 3 and 5-year incidence rate of liver metastasis was 25.0% and 33.3% , respectively. The risk factors of liver metastasis were lymph node metastasis (LNM), tumor invasive depth ( TID), histological grading (G) and preoperative serum tumor markers ( PSMs ). The mathematic model was: logit (P) = - 0. 931 + 0. 973 x LNM + 0. 302 x TID + 0. 637 x G + 0. 042 x PSMs. Conclusion The risk factors of liver metastasis were LNM, TID, G and PSMs, and the mathematic model could be set up.
出处 《国际肿瘤学杂志》 CAS 2013年第5期392-395,共4页 Journal of International Oncology
关键词 结直肠肿瘤 肿瘤转移 危险因素 Colorectal neoplasms Neoplasm metastasis Liver Risk factors
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