摘要
现今肿瘤的转移与复发是导致肿瘤患者死亡的主要原因,人们在肿瘤方面的研究方面也有了一个飞跃,随着研究的深入,发现肿瘤与干细胞之间关系密切,Reya认为肿瘤干细胞(tumor stem cell,TSC)是肿瘤细胞中小部分细胞具有自我更新及分化的能力,并维持肿瘤的形成及生长的细胞,这一小部分细胞被称为肿瘤干细胞。随着越来越多的实验研究,肿瘤干细胞对癌症的诊断、治疗和预后方面都有重要意义。
出处
《齐齐哈尔医学院学报》
2013年第9期1352-1353,共2页
Journal of Qiqihar Medical University
参考文献15
-
1Reya T, Morrison S J, Clarke MF, et al. Stem cells, cancer, and cancer stern cells. Nature,2001,414 : 105-111.
-
2Mackillop WJ, Ciampi A, Till JE, et al. A stem cellmodel of human tumor growth, implications for tumor cell clonogenic assays. Journal of the National Cancer Institute, 1983,70 : 9-16.
-
3Guo W, Lasky J L, Wu H. Cancer stem cells. International Pediatric Research Foundation,2006,59 (4) : 59 - 64,.
-
4Weissman IL. Normal and neoplastic stem cells. Novartis Found Syrup ,2005,265:35-50.
-
5Jamieson CH, Ailles LE, Dylla S J, et al. Granulocyte - macro - phage progenitors as candidate leukemic stem cells in blast - crisis CML. N Engl J Med ,2004 ,351:657-667.
-
6Li Y, Welm B, Podsypanina K, et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor ceils. Proc Natl Aead Sei USA ,2003,100 : 15853-15858.
-
7Kim CF, Jackson EL,Woofenden AE, et al. Identification of bron -ehioalveolar stem cells in normal lung and lung cancer. Cell, 2005 ,Jun 17 ; 121 (6) :823-835.
-
8A1 - Hajj M, MS Wicha, A Benito - Hernandez, SJ Morrison and MF Clarke. Prospective identifi cation of tumorigenic breastcancer ceils. Proc Natl Acad Sci USA ,2003, May 27,100 (11 ) :6890.
-
9Singh SK, Clarke ID, Terasaki M. Identification of a Cancer Stem Cell in Human Brain Tumors. Nature, 2004, Nov 18,432 ( 7015 ) : 396-401.
-
10Yin AH, Miraglia S, Zanjani ED, et al. AC133, a novel marker for human hematopoletic stem and progenitor ceils. Blood, 1997,90 (12) :5002-5012.
二级参考文献18
-
1Heppner GH. Tumor heterogeneity. Cancer Res 1984; 44:2259-2265
-
2Fleuren GJ, Gorter A, Kuppen PJ, Litvinov S,Warnaar SO. Tumor heterogeneity and immunotherapy of cancer, lmmunol Rev 1995; 145:91-122
-
3Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111
-
4Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977; 197:461-463
-
5Osawa M, Hanada K, Hamada H, Nakauchi H.Long-term lymphohematopoietic reconstitution by a single CD34-1ow/negative hematopoietic stem cell. Science 1996; 273:242-245
-
6Passegue E, Jamieson CH, Ailles LE, Weissman IL.Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA 2003; 100:11842-11849
-
7Marx J. Cancer research. Mutant stem cells may seed cancer. Science 2003; 301:1308-1310
-
8Rhyu MS, Knoblich JA. Spindle orientation and asymmetric cell fate. Cell 1995; 82:523-526
-
9Al-Hajj M, Wicha MS, Benito-Hernandez A,Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983-3988
-
10Dick JE. Breast cancer stem cells revealed. Proc Natl Acad Sci USA 2003; 100:3547-3549
共引文献15
-
1张世光,成玉,高英堂,杜智,陈力.肿瘤干细胞及肝癌肿瘤干细胞[J].细胞生物学杂志,2007,29(1):6-10.
-
2王锡山,刘彦龙,杨艳梅.大肠癌细胞系Lovo中亚群(SP)细胞的分离培养和鉴定[J].世界华人消化杂志,2007,15(9):953-959. 被引量:8
-
3殷涛,王春友,熊炯炘,陶京,赵刚.Vimentin在胰腺癌细胞中的表达及临床意义[J].世界华人消化杂志,2007,15(36):3822-3825. 被引量:6
-
4千年松,李韧,于衡超,曹云新,张福琴,窦科峰.罗丹明123分离肝癌细胞系HepG2异质性亚群的鉴定[J].世界华人消化杂志,2008,16(9):941-945. 被引量:3
-
5张宏颖,唐建武,朱文婷,胡春秀,许国旺.小鼠腹水型肝癌淋巴道高转移细胞系HCa-P/L_6细胞模型的建立及其药物敏感性的评价[J].大连医科大学学报,2008,30(4):297-304. 被引量:2
-
6颜政,方驰华.多药耐药相关蛋白在人肝细胞癌亚群细胞中的表达及意义[J].青海医学院学报,2008,29(3):145-148. 被引量:1
-
7王开,康非吾,朱炎.实体瘤干细胞特异性表面标记物的研究进展[J].口腔颌面外科杂志,2009,19(1):53-56. 被引量:2
-
8刘平平,李晓明.实体肿瘤干细胞分离鉴定技术的研究进展[J].西南军医,2009,11(3):489-492. 被引量:3
-
9姜丽华,乔丽津.肿瘤干细胞的研究进展[J].中国小儿血液与肿瘤杂志,2009,14(5):235-237. 被引量:2
-
10宋凯,杨硕菲,吴俊华,江春平.肝癌干细胞的研究进展[J].世界华人消化杂志,2009,17(36):3704-3710. 被引量:6
同被引文献28
-
1Zhou ZH,Ping YF,Yu SC,et al.A novel approach to the identification and enrichment of cancer stem cells from a cultured human glioma cell line[J].Cancer Lett,2009,281(1):92-99.
-
2Boman BM.Wicha MS.Cancer stem cells:a step toward the cure[J].J Clin Oncol,2008,26(17):2795-2799.
-
3Karam SM,Tomasetto C,Rio MC.Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice[J].Cell Prolif.2008,41(6):923-935.
-
4Heidt DG,Li C,Mollenberg N,et al.Identification of pancreatic cancer stem cells[J].J Surg Res,2006,130(2):194-195.
-
5Patrawala L,Calhoun-Davis T,Schneider-Broussard R,et al.Hierarchical organization of prostate cancer cells in xenograft tumors:the CD_(44)~+alpha2betal+cell population is enriched in tumor-initiating cells[J].Cancer Res,2007,67(14):6796-6805.
-
6Vermeulen L.Todaro M,De Sousa Mello F,et al.Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity[J].Proc Natl Acad Sci USA,2008,105(36):13427-13432.
-
7Qiao XT,Ziel JW,Mckimpson W,et al.Prospective identification of a multilineage progenitor in murine stomach epithelium[J].Gastroenterology,2007,133(6):1989-1998.
-
8Barker N,Huch M,Kujala P,et al.Lgr5(+ve)stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro[J].Cell Stem Cell,2010,6(1):25-36.
-
9Simon E.Petke D.Buger C,et al.The spatial distribution of LGR5+cells correlates with gastric cancer progression[J].PLoS One,2012,7(4):e35486.
-
10Nam KT,Lee HJ,Sousa JF,et al.Mature chief cells are cryptic progenitors for metaplasia in the stomach[J].Gastroenterology,2010,139(6):2028-2037.
二级引证文献2
-
1鲁明,付波,马翔,吴冬冬,赵庆洪.干细胞标志物CD133与胃癌临床特征的相关性研究[J].中国医药科学,2016,6(21):22-28.
-
2谷瀚博,蔡相军,李医明,刘洪涛,王晓欢.NUMB与SIP1在胃癌组织中的表达水平及其临床意义[J].疑难病杂志,2017,16(4):373-376. 被引量:2
-
1苏进,许新华.肿瘤干细胞及肿瘤耐药研究进展[J].广东医学,2009,30(9):1393-1394. 被引量:3
-
2杨静爱,苏维祥,麦秋萍,解继胜,黄瑞雅.肿瘤干细胞的研究及临床意义[J].四川解剖学杂志,2007,15(3):34-36. 被引量:1
-
3何明生,郭涛.肿瘤干细胞发生机制的研究现状[J].中国组织工程研究与临床康复,2007,11(28):5618-5621. 被引量:1