摘要
目的 探讨机械通气治疗急性重度有机磷农药中毒呼吸衰竭的时机。方法 将115例急性重度有机磷农药中毒呼吸衰竭患者,根据机械通气不同指征分为观察组A 40例、观察组B 38例、对照组37例。对三组治愈率、吸入性肺炎发生率、机械通气时间、住院时间进行统计学分析。结果 观察组A治愈率（97.5%）明显高于对照组（83.4%）和观察组B（92.1%）（P〈0.05或P〈0.01）;观察组A吸入性肺炎（2例）明显少于对照组（8例）（P〈0.05）;观察组A、观察组B住院时间［（4.46±0.51）d、（7.11±0.83）d］和机械通气时间［（55.40±5.24）h、（79.47±2.44）h］均明显短于对照组［（10.40±1.12）d、（100.30±2.15）h］（均P〈0.01）;观察组A住院时间［（4.46±0.51）d］和机械通气时间［（55.40±5.24）h］均明显短于观察组B［（7.11±0.83）d、（79.47±2.44）h］（均P〈0.01）。结论 呼吸频率≥30次/min＜34次/min或≤10次/min,或自主呼吸减弱,血气分析提示低氧血症（60 mm Hg＜PaO2≤70 mm Hg）是机械通气治疗急性重度有机磷农药中毒呼吸衰竭的最佳时机。
Objective To explore the treatment opportunity of mechanical ventilation for acute severe organophosphorus pesticide poisoning patients with respiratory failure.Methods According to the different indications of mechanical ventilation,115 acute severe organophosphorus pesticide poisoning patients with respiratory failure were divided into the observation group A（40 cases）,the observation group B（38 cases）and the control group（37 cases）.The cure rate,aspiration pneumonia incidence,duration of mechanical ventilation,length of hospital stay of the three groups were analyzed.Results The cure rate of the observation group A（97.5%） was significantly higher than that of the control group（83.4%）and the observation group B（92.1%）（P〈0.05 or P〈0.01）;The aspiration pneumonia of the observation group（2 cases） was significantly less than that of the control group（8 cases）（P〈0.05）;The hospitalization time[（4.46±0.51）d,（7.11±0.83）d]and the duration of mechanical ventilation[（55.40±5.24）h,（79.47±2.44）h]of the observation group A and the observation group B were significantly shorter than those of the control group[（10.40 ± 1.12）d,（100.30± 2.15）h]（all P〈0.01）;The hospitalization time and the duration of mechanical ventilation of the observation group A[（4.46±0.51）d,（55.40±5.24）h]were significantly shorter than those of the observation group B[（7.11±0.83）d,（79.47±2.44）h]（all P〈0.01）.Conclusion Respiratory rate≥30 times/min and 〈34 times/min or ≤ 10 times/min,or spontaneous breathing weakened,and blood gas analysis prompted hypoxemia（60 mm Hg〈PaO2≤70 mm Hg）is best opportunity of mechanical ventilation for acute severe organophosphorus pesticide poisoning patients with respiratory failure.
出处
《中国基层医药》
CAS
2013年第11期1643-1645,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
有机磷农药
中毒
呼吸衰竭
机械通气
Organophosphate pesticides
Poisoning
Respiratory failure
Mechanical ventilation
