摘要
Lipocalin型前列腺素D合成酶 (L PGDS)在男性生殖系统中广泛表达 ,且表达程度与男性生殖器官的发育成熟有关。附睾中L PGDS的合成可能受睾酮和睾丸因子的调节 ,而局部生殖细胞对睾丸L PGDS的表达亦起一定作用。男性生殖系统中的L PGDS为一种多形性的糖蛋白 ,可催化精浆中PGD2 的产生。L PGDS为一种生育相关蛋白 ,且与类视色素的运输和跨越血 睾屏障或血 附睾屏障的物质转运有关 ;PGD2 不仅与精子在女性生殖道中运行有关 ,亦可能与免疫性不育有关。人睾丸L PGDS的体外克隆和表达的研究 ,对进一步探索L
Lipocalin type prostaglandin D synthase (L PGDS) is widely expressed in male reproductive system, and the extent of its expression is related to the development and maturation of male reproductive organs. The synthesis of L PGDS in epididymis is possibly regulated by testosterone and some factors secreted by testis, while the expression of L PGDS in testis is affected by local spermatogenic cells. The L PGDS which catalyzes prostaglandin D 2 (PGD 2) production in seminal plasma is a kind of glycoprotein with multiple patterns in male reproductive system. L PGDS is a fertility associated protein and related to the transportation of retinoid and substances which transfer through blood testis or blood epididymis barrier. Furthermore, PGD 2 is related to not only the transfer of sperm through female reproductive ducts but also immunity associated infertility. Cloning and expression of human testis L PGDS in vitro are very important to further exploration of L PGDS function in male reproductive system.
出处
《中华男科学杂志》
CAS
CSCD
2000年第2期119-122,共4页
National Journal of Andrology
基金
解放军九五计划生育基金!资助项目 (编号 :军计生 98 0 4号 )
关键词
前列腺素D合成酶
男性生殖
前列腺素D2
Lipocalin type prostaglandin D synthase
Male reproduction
Prostaglandin D 2
