摘要
目的探讨初诊2型糖尿病患者的甲状腺功能变化,以及不同甲状腺功能状态下的临床特点。方法选取住院初诊2型糖尿病患者164例,检测血清总T3(TT3)、总T4(TT4)、游离T3(FT3)、游离T4(FT4)、促甲状腺激素(TSH)水平。比较亚临床甲状腺功能减退症(SCH)组、低T3综合征组和甲状腺功能正常组之间糖代谢、脂代谢和胰岛功能等指标的差异。结果初诊2型糖尿病患者中甲状腺功能异常者占35.37%,其中13.41%为SCH,18.29%为低T3综合征,低T3综合征组患者的血糖水平较甲状腺功能正常组明显增高(P<0.05),空腹C肽(CP0)及餐后2 h C肽(CP2)较甲状腺功能正常组明显降低(P<0.05)。SCH组患者的CP0、CP2较甲状腺功能正常组明显增高(P<0.05)。结论初诊2型糖尿病患者的甲状腺功能异常的发生率较高,主要表现为低T3综合征和SCH,合并SCH的2型糖尿病患者C肽水平升高,合并低T3综合征者C肽水平降低。
Objective To investigate the changes of the thyroid function and the clinical characteristics in different thyroid functional status of newly diagnosed type 2 diabetes mellitus （T2DM） patients. Methods 164 patients with newly diagnosed T2DM were studied. Serum total T3 （TT3）, total T4 （TT4）, free T3 （FT3）, free T4 （FT4） and thyroid stimulating hormone （TSH） were measured. Patients were classified as the subclinical hypothyroidism （SCH） group, low T3 syndrome group and the normal thyroid function group. The differences in glucose metabolism, lipid metabolism, β cell function and other indices were compared. Results 35.37% of the 164 patients showed thyroid dysfunction, 13.41% had SCH, 18.29% exhibited low T3 syndrome. In low T3 syndrome group, the levels of glucose were significantly higher than the normal thyroid function group （ P 〈 0. 05 ） , and the C-peptide levels of fasting and 2 h after 100 g carbohydrate were significantly lower（P 〈 0.05 ）. The C-peptide levels of fasting and 2 h in SCH group were significantly higher than the normal thyroid function group（ P 〈 0.05 ）. Conclusion The prevalence of thyroid dysfunction in newly diagnosed T2DM patients is high. The C-peptide levels are higher in the T2DM patients with SCH and lower in the T2DM patients with low T3 syndrome.
出处
《安徽医科大学学报》
CAS
北大核心
2013年第6期675-677,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省科技厅年度重点项目(编号:12070403068)
安徽省高等学校省级自然科学基金研究项目(编号:KJ2012Z177)
安徽医科大学校级科研基金(编号:2012xkj057)
