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双侧甲状腺切除术后甲状旁腺功能减退临床因素分析及防治 被引量:30

Analysis of the clinical factors and treatment effect of hypoparathyroidism after bilateral thyroidectomy
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摘要 目的:探讨双侧甲状腺切除术后患者甲状旁腺功能减退与各临床因素的关系,总结术后甲状旁腺功能减退的预防和治疗。方法:2011年1—12月行双侧甲状腺手术患者193例,所有患者于术后第1、2天检测血钙及甲状旁腺素(PTH),术后1、3、6个月随访血钙和PTH。术后PTH低于正常值患者予口服碳酸钙和维生素D。结果:193例患者中25例(13.0%)出现甲状旁腺功能减退,其中19例(9.8%)为暂时性甲状旁腺功能减退,6例(3.1%)为永久性甲状旁腺功能减退。不同年龄、性别患者术后甲状旁腺功能减退发生率差异无统计学意义(P>0.05)。甲状腺恶性肿瘤、术中行淋巴结清除患者术后甲状旁腺功能减退发生率(24.7%、20.9%)高于良性肿瘤、未行淋巴结清除患者(5.2%、8.7%,P<0.01、P<0.05)。术中有甲状旁腺误切患者与无误切患者术后甲状旁腺功能减退发生率差异无统计学意义(24.0%vs 11.3%,P=0.08)。永久性甲状旁腺功能减退患者中行颈淋巴结清除者100%(6/6)、甲状旁腺误切者83.3%(5/6),两者比例均高于暂时性甲状旁腺功能减退患者(P<0.05、P<0.01)。25例甲状旁腺功能减退患者补充碳酸钙和维生素D后1例出现低钙血症。结论:甲状旁腺功能减退与患者的年龄、性别无关,与患者手术范围有关,颈淋巴结清除和甲状旁腺误切更易导致永久性甲状旁腺功能减退。术后选择性补充碳酸钙和维生素D可以有效减少低钙血症的发生。 Objective: The most common complication following a bilateral thyroidectomy ishypoparathyroidism. The aim of this study was to analysis of the clinical factors of hypoparathy- roidism after bilateral thyroidectomy and the medical treatment to prevent hypocalcaemia. Metl- ods: We studied 193 bilateral thyroidectomy patients between January 2011 and November 2011. PTH and serum calcium level were assayed 1 day before, 1 day, 2 days, 1 month, 3 months and 6 months after thyroidectomy.
出处 《中国现代普通外科进展》 CAS 2013年第5期373-375,379,共4页 Chinese Journal of Current Advances in General Surgery
关键词 甲状腺切除 低钙血症 甲状旁腺功能减退 甲状旁腺激素 Thyroidectomy Hypocalcemia Hypoparathyroidism Parathyroid hormone
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  • 1李强,韩晓婷,秦珊,王萍萍.甲状腺切除术中预防甲状旁腺损伤的体会[J].中国现代普通外科进展,2009,12(3):265-266. 被引量:11
  • 2Costanzo M, Marziani A, Condorelli F, et al. Post-thyroidectomy hypocalcemic syndrome: predictive value of early PTH. Preliminary results[J]. Ann ltal Chit, 2010,81 (4):301-305.
  • 3Lo CY. Parathyroid aatotransplantation during thyroidectomy[J]. ANZ J Surg, 2002,72(12):902-907.
  • 4Zedenius J, Wadstrom C, Delbridge L. Routine autotransplantation of at least one parathyroid gland during total thyroidectomy may reduce permanent hypoparathyroidism to zero[J]. Aust N Z J Surg, 1999,69 ( 11 ):794-797.
  • 5Noordzij JP, Lee SL, Bernet VJ, et al. Early prediction of hypocal- eemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies [J]. J Am Coil Surg, 2007,205(6):748-754.
  • 6Asari R, Passler C, Kaczirek K, et al. Hypoparathyroidism after total thyroidectomy: a prospective study[J]. Arch Surg, 2008,143 (2):132- 137.
  • 7Tartaglia F, Giuliani A, Sgueglia M, et al. Prevention of postopera- tive hypocalcemia with routine oral calcium and vitamin D sup- plements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection [J]. Cancer, 2009,115(2):251-258.
  • 8Sabour S, Manders E, Steward DL. The role of rapid PACU parathy- roid hormone in reducing post-thyroidectomy hypocalcemia[J]. Oto- laryngol Head Neck Surg, 2009,141(6):727-729.

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