摘要
目的:观察三联疗法对消化性溃疡患者血清血管内皮细胞生长因子(VEGF)及碱性成纤维细胞生长因子(bFGF)水平的影响。方法:将80例消化性溃疡患者随机分为观察组与对照组,观察组给予奥美拉唑、克拉霉素和阿莫西林三联疗法,对照组单独给予奥美拉唑治疗,两组疗程均为4周,采用ELISA法检测并比较两组患者治疗前、后血清VEGF和bFGF水平及变化。结果:治疗4周后,两组患者治疗前和治疗后血清VEGF和bFGF水平比较差异均有统计学意义(P<0.05),两组治疗前、后差值比较差异亦有统计学意义(P<0.05),患者血清VEGF表达水平与bFGF表达水平呈明显正相关(P<0.01)。结论:三联疗法在溃疡愈合过程中可能通过增加VEGF和bFGF表达促进溃疡的愈合,有效提高溃疡的愈合质量。
Objective. To observe the influence of triple therapy on levels of VEGF and bFGF in patients with peptic ulcer. Methods： A total of 80 patients with peptic ulcer were randomly divided into ob- servation group and control group, the observation group was given omeprazole, amoxicillin and clarithro- mycin triple therapy, while the control group was given omeprazole treatment, both groups were treated for 4 weeks. Changes in serum VEGF and bFGF levels before and after the treatment were detected using ELISA methods to. Results： After treatment, significant difference in serum VEGF and bFGF levels were observed in both groups comparing with the levels before the treatment （P〈0. 05）, and degree of changes were significant different between the two groups （P〈0. 05）. Besides, expression levels of VEGF posi- tively correlated with bFGF expression levels （P 〈0.01）. Conclusion： The triple therapy may promote the ulcer healing process by increasing VEGF and bFGF expression, thus can effectively improve the quali- ty of ulcer healing.
出处
《海南医学院学报》
CAS
2013年第8期1084-1086,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210754)~~
