摘要
目的探讨血清炎性因子白介素6(IL-6)、白介素8(IL-8)、白介素10(IL-10)及肿瘤坏死因子α(TNF-α)在重症急性胰腺炎(SAP)中所起的作用,及其对SAP继发多器官功能不全综合征(MODS)的预测意义。方法选取我院急诊外科2009—2012年就诊的SAP患者40例(SAP组),将其按是否合并MODS分为MODS组(10例)和非MODS组(30例)。分别于发病就诊后第0.5、1、2、3、5、7天静脉取血,测定IL-6、IL-8、IL-10、TNF-α水平,并与40例体检健康者进行比较(正常健康组)。结果 SAP组患者IL-6、IL-8、IL-10在每个时段与正常健康组比较,差异均有统计学意义(P<0.005);SAP组患者IL-6、IL-8、IL-10、TNF-α水平在发病后即升高,第1～3天达峰值后开始下降。MODS组TNF-α、IL-6、IL-8水平在就诊后前3d均高于非MODS组,差异有统计学意义(P<0.01);MODS组IL-10水平在就诊后2～5d均高于非MODS组,差异有统计学意义(P<0.01)。结论 SAP能引起明显的细胞因子反应,动态观察患者血清细胞因子IL-6、IL-8、IL-10、TNF-α水平的变化,有助于病情的评估及预后的判断。
Objective To research the role of interleukin 6（IL-6）,interleukin 8（IL-8）,interleukin 10（IL-10） and tumor necrosis factor alpha（TNF-α） in severe acute pancreatitis（SAP） in the role,and on SAP with multiple organ dysfunction syndrome（MODS） prediction significance.Methods 40 SAP patients in our hospital from 2009 to 2012 were emergency surgery patients（SAP group）,according to its whether complicated with MODS were divided into MODS group（10 cases） and non MODS group（30 cases）.The difference in incidence after visiting the 0.5,1,2,3,5,7 days of venous blood,determination of content of IL-6,IL-8,IL-10,TNF-α,and compared with 40 healthy persons（normal group）.Results Patients in SAP group IL-6,IL-8,IL-10 compared with normal group in each time period,the differences were statistically significant（P0.005）;IL-6,IL-8,IL-10,TNF-α content in the SAP group increased after the onset,1~3 Tianda peak began to decline after.In MODS group,TNF-α,IL-6,IL-8 after the doctor before 3d were significantly higher than the MODS group,the differences were statistically significant（P〈0.01）;The content of IL-10 in treatment group MODS after 2~5d were significantly higher than that in non MODS group,the differences were statistically significant（P〈0.01）.Conclusion SAP can cause the cytokine reaction obviously,to observe the changes of serum cytokines in patients with IL-6,IL-8,IL-10,TNF-α,and assess the prognosis of the judgment to the illness.
出处
《实用心脑肺血管病杂志》
2013年第6期28-31,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
胰腺炎
急性坏死性
白介素
肿瘤坏死因α
预后
Pancreatitis
acute necrotizing
Interleukins
Tumor necrosis factor alpha
Prognosis
