摘要
1例81岁女性患者因肺部真菌感染静脉滴注氟康唑200 mg,1次/d。输注10 min后患者心电图显示频发室性早搏,随即静脉注射利多卡因及静脉滴注氯化钾,10 min后心电图显示尖端扭转型室性心动过速,继而出现心室颤动。立即给予胸外按压和电除颤、并静脉给予利多卡因、硫酸镁及门冬氨酸钾镁等治疗。次日输注氟康唑注射液5 min后再次发生尖端扭转型室性心动过速和心室颤动。停用氟康唑注射液,改用伊曲康唑注射液抗真菌治疗。此后未再出现尖端扭转型室性心动过速和心室颤动。
An 81-year-old woman with pulmonary fungal infection received an Ⅳ infusion of fluconazole 200 mg once daily.Ten minutes after infusion started,the patient＇s electrocardiogram showed frequent ventricular premature beats,and then an Ⅳ push of lidocaine and an Ⅳ infusion of potassium chloride were given immediately.Ten minutes later,the patient＇s electrocardiogram showed torsades de pointes and ventricular fibrillation.She was immediately treated with chest compression and defibrillation,followed by Ⅳ lidocaine,Ⅳ magnesium sulfate and Ⅳ potassium magnesium aspirate.The next day,torsades de pointes and ventricular fibrillation occurred again 5 minutes after an Ⅳ infusion of fluconazole.Fluconazole was withdrawn immediately and her therapy was changed to itraconazole injection for antifungal therapy.After this change,her torsades de pointes and ventricular fibrillation did not recur.
出处
《药物不良反应杂志》
CSCD
2013年第1期42-43,共2页
Adverse Drug Reactions Journal
