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刺五加苷食用安全性毒理学评价 被引量:4

Food Safety and Toxicological Assessment of Eleutheroside
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摘要 目的:研究刺五加苷的食用安全性,为促进其合理开发利用提供科学依据。方法:根据《保健食品检验与评价技术规范》,对刺五加苷进行急性毒性实验、小鼠骨髓微核实验、Ames实验、小鼠精子畸变实验、大鼠30d喂养实验。结果:刺五加苷对雌雄小鼠的急性经口的最大耐受剂量(MTD)均大于20g/kg(以体质量计);Ames实验、小鼠骨髓微核实验、小鼠精子畸形实验均为阴性;大鼠30d喂养实验中,实验动物生长情况良好,血液学检查、生化学检查、主要脏体比及组织学检查结果与对照组相比,均无明显差异。结论:刺五加苷属实际无毒物质,未显示有遗传毒性,初步估计其未观察到损害作用的剂量(NOAEL)为20g/kg。 Objective: To evaluate the safety of eleutheroside, and to provide scientific support for the reasonable utilization and development of eleutheroside. Methods: According to the national standard procedures and methods in food safety and toxicological evaluation, a series of toxicological studies on the ingestion of eleutheroside were conducted, which included acute toxicity, genetic toxicity and subacute toxicity tests. Results: For acute toxicity, the maximum tolerated dose (MTD) was higher than 20 g/kg. The results of Ames test, mouse bone marrow micronucleus test and mouse sperm abnormality test were negative. After 30 d of feeding, rats showed no significant difference in body growth, organ development or histological observation. Conclusion: Eleutheroside is actually non-toxic with no genetic toxicity. No adverse effect of eleutheroside at 20 g/kg has been observed during trails for 30 d.
出处 《食品科学》 EI CAS CSCD 北大核心 2013年第11期258-262,共5页 Food Science
基金 辽宁省自然科学基金项目(2011205001)
关键词 刺五加苷 急性毒性 遗传毒性 亚急性毒性 食品安全 eteutheroside acute toxicity genetic toxicity subacute toxicity food safety
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参考文献17

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