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不同剂量左旋肉碱改善维持性血透患者贫血的疗效观察 被引量：5

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摘要 目的:观察不同剂量左旋肉碱改善维持性血透患者贫血的疗效。方法 :将90例每周透析3次的维持性血透患者随机分为对照组A和治疗组B、C各30例,治疗组B、C分别于每次血液透析结束时静脉注射左卡尼汀20、40 mg/kg,对照组不予左卡尼汀注射液,疗程24周。观察3组治疗前后血红蛋白、红细胞压积、红细胞生成素(EPO)用量、血浆游离左旋肉碱浓度及EPO抵抗指数(ERI)的情况。结果:治疗24周后治疗组患者的血红蛋白、红细胞压积均明显高于治疗前及对照组,EPO用量较对照组减少,在大剂量左旋肉碱治疗组中尤为明显(P<0.05);大剂量左旋肉碱治疗组中EPO抵抗患者的血红蛋白及红细胞压积较常规剂量左旋肉碱治疗组及对照组升高明显,ERI下降(P<0.05)。结论:左旋肉碱可以改善维持性血透患者的贫血情况,减少EPO用量,大剂量左旋肉碱可改善维持性血透患者的EPO抵抗。
作者 黄钱娥 黄宇清 郑林鸿 陈汉威
机构地区 中山大学附属博济医院(增城市人民医院)肾内科
出处 《实用医学杂志》 CAS 北大核心 2013年第11期1841-1843,共3页 The Journal of Practical Medicine
关键词 贫血 血液透析 左旋肉碱 红细胞生成素抵抗
分类号 R692.5 [医药卫生—泌尿科学]
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参考文献12

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同被引文献64

  • 1曾宇然,谭凤娇.蔗糖铁治疗血液透析患者贫血的疗效观察[J].中国社区医师·医学专业,2011,13(7):71.
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实用医学杂志
2013年 第11期

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