摘要
目的:评价人重组凝血因子Ⅶa在Stanford A型主动脉夹层手术止血中的疗效。方法:对12例手术中使用人重组凝血因子Ⅶa的患者和20例未使用人重组凝血因子Ⅶa的患者进行回顾性分析,观察手术止血时间,术后24h引流量,术后24h浓缩红细胞使用量,术后24h血浆使用量。结果:rFⅦa组的手术止血时间明显缩短,与对照组比较差异具有统计学意义[(166±33)min vs(206±48)min,P<0.05];rFⅦa组术后24h引流量低于对照组[(666±195)mL vs(824±210)mL,P<0.05];rFⅦa组术后24h血浆使用量低于对照组[(525±157)mL vs(696±211)mL,P<0.05];rFⅦa组术后24h浓缩红细胞使用量与对照组无统计学差异[(3.2±1.3)Uvs(3.9±1.9)U,P>0.05]。结论:在Stanford A型主动脉夹层手术中使用人重组凝血因子Ⅶa有良好的止血效果,可缩短手术时间,减少引流量,节约血制品的使用。
AIM: To evaluate the efficacy of recombinant coagulation factor Ⅶa(rFⅦa) for intraoperative bleeding management in Stanford type A aortic dissection.METHODS: 12 cases using rFⅦa in Stanford type A aortic dissection surgery as the experimental group,the remaining 20 cases without using rFⅦa was as the control group.The parameters of time of surgical hemostasis,the drainage volume in 24 h after operation,requirement of plasma and red blood cells in 24 h after operation were compared.RESULTS:In rFⅦa group,the significant reductions were observed in time of surgical hemostasis [(166±33) min vs(206±48) min,P〈0.05],the drainage volume in 24 h after operation [(666±195) mL vs(824±210) mL,P〈0.05] and the requirement of plasma in 24 h after operation [(525±157) mL vs(696±211) mL,P〈0.05],but the requirement of red blood cells in 24 h after operation was not significantly different between the two groups [(3.2±1.3) U vs(3.9±1.9) U,P〈0.05].CONCLUSION: The use of rFⅦa in Stanford type A aortic dissection surgery has a good hemostatic effect that can shorten the operation time,reduce the drainage volume,and save blood products.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2013年第5期524-526,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
人重组凝血因子Ⅶa
主动脉夹层
止血
Recombinant coagulation factor Ⅶa(rFⅦa)
Aortic dissection
Hemostasis