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多系统萎缩患者的认知功能障碍 被引量：2

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摘要 多系统萎缩（multiple system atrophy，MSA）是一种散发进行性神经系统多部位受累的变性疾病。临床主要表现为帕金森样症候、小脑性共济失调、锥体束征和自主神经系统障碍等。少突胶质细胞内包涵体是该病的特征性病理学标志物，主要成分是一种高度磷酸化的α-突触核蛋白[1]。
作者 宋东东 戚晓昆
机构地区 第二军医大学海军临床医学院神经内科 海军总医院神经内科
出处 《中华内科杂志》 CAS CSCD 北大核心 2013年第6期517-518,共2页 Chinese Journal of Internal Medicine
关键词 多系统萎缩 认知功能障碍 自主神经系统 小脑性共济失调 Α-突触核蛋白 患者 细胞内包涵体 变性疾病
分类号 R74 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献14

  • 1Gihnan S, Low PA, Quinn N,et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci, 1999,163:94- 98.
  • 2Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology, 2008,71:670-676.
  • 3李丽萍,戚晓昆,刘建国,段枫,赵敏.以认知功能障碍为首发症状的多系统萎缩一例[J].中华内科杂志,2008,47(1):83-83. 被引量：8
  • 4Brown RG, Lacomblez L, Landwehrrneyer BG, et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain, 2010, 133 ( Pt 8 ) : 2382- 2393.
  • 5Gilman S, May S J, Shults CW, et al. The North American Multiple System Atrophy Study Group. J Neural Transm, 2005, 112:1687-1694.
  • 6何振巍,张朝东.多系统萎缩合并认知功能障碍患者的临床研究[J].中国医科大学学报,2010,39(3):238-239. 被引量：8
  • 7Burk K, Daum I, Rub U. Cognitive function in multiple system atrophy of the cerebellar type. Mov Disord, 2006,21:772-776.
  • 8Kawai Y, Suenaga M, Takeda A, et al. Cognitive impairments in multiple system atrophy : MSA-C vs MSA-P. Neurology, 2008,70 (16 Pt 2) :1390-1396.
  • 9Chang CC, Chang YY, Chang WN, et al. Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration. Eur J Neurol,2009,16 : 1144-1150.
  • 10Bhattacharya K, Saadia D, Eisenkraft B, et al. Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm. Arch Neurol, 2002,59:835-842.

二级参考文献11

  • 1Wenning GK,Stefanova N,Jellinger K,et al. Multiple system atrophy : a primary oligodendrogliopathy [J]. Ann Neurol, 2008,64 (3) : 239-246.
  • 2Jellinger KA. More frequent Lewy bodies but less frequent Alzheimertype lesions in multiple system atrophy as compared to age-matched control brains [ J ]. Acta Neuropathol, 2007,114( 3 ) : 299-303.
  • 3Wenning GK, Brown R. Dementia in multiple system atrophy:does it exist? [J]. EurJ Neurol,2009,16(5 ) :551-552.
  • 4Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of MSA [ J ]. Neurology, 2008,71 (9) : 670-676.
  • 5Kawai Y, Suenaga M, Takeda A, et al. Cognitive impairments in multiple system atrophy : MSA-C vs MSA-P [J]. Neurology, 2008,70( 16 Pt2) : 1390-1396.
  • 6Burk K, Daum I, Rub U. Cognitive function in MSA of cerebellar type [J]. Mov Disord,2006,21 (6) :772-776.
  • 7De Jong BM. Neurological picture. MRI development of early white matter signs in cerebellar-type muhisystem atrophy [ J ]. Neurol Neurosurg Psychiatry, 2009,80( 7 ) : 797-798.
  • 8Nagayama H,Yamazaki M,Ueda M,et al. Low myocardial MIBG uptake in multiple system atrophy with incidental Lewy body pathology:an autopsy case report[J]. Movement Disorders,2008,23 (7): 1055-1057.
  • 9Kitamaya M, Wada-Isoe K, Irizawa Y, et al. Assessment of dementia in patients with multiple system atrophy [ J ]. Eur J Neurol, 2009,16 (5) :589-594.
  • 10Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci, 1999, 163: 94-98.

共引文献12

同被引文献18

  • 1刘建军,熊葶.多系统萎缩并发喘鸣一例报告[J].中华神经科杂志,2005,38(10):647-647. 被引量：2
  • 2王胜军,迟兆富,吴伟,侯金文,陈雯.多系统萎缩的临床与MRI特征[J].临床神经病学杂志,2006,19(2):86-89. 被引量：15
  • 3Bleasel JM,Wong JH,Halliday GM,et al.Lipid dysfunction and pathogenesis of multiple system atrophy.Acta Neuropathol Commun,2014,2:15.
  • 4Gilman S,Wenning GK,Low PA,et al.Second consensus statement on the diagnosis of multiple system atrophy.Neurology,2008,71:670-676.
  • 5Shigemoto Y,Matsuda H,Kamiya K,et al.In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8plus DARTEL for VBM.Neuroimage Clin,2013,2:491-496.
  • 6Pedroso JL,Rivero RL,Barsottini OG.“Hot cross bun”sign resembling multiple system atrophy in a patient with Machado-Joseph disease.Arq Neuropsiquiatr,2013,71:824.
  • 7Wenning GK,Krismer F.Multiple system atrophy.Handb Clin Neurol,2013,117:229-241.
  • 8Perrotta A,Bolla M,Serrao M,et al.Enhanced temporal pain processing in multiple system atrophy.Neurosci Lett,2013,555:203-208.
  • 9Multiple-System Atrophy Research Collaboration.Mutations in COQ2in familial and sporadic multiple-system atrophy.N Engl J Med,2013,369:233-244.
  • 10Wenning GK,Geser F,Krismer F,et al.The natural history of multiple system atrophy:aprospective European cohort study.Lancet Neurol,2013,12:264-274.

引证文献2

二级引证文献11

中华内科杂志
2013年 第6期

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