摘要
目的 :评价胺碘酮在治疗心房纤颤中对心肌复极的影响。方法 :测量了 4 8例用胺碘酮转复和维持治疗房颤患者的QT间期与QT离散度 ,并与 2 1例阵发房颤和 4 3例健康对照组比较。结果 :阵发房颤动组与健康对照组QT间期和QT离散度无差异 (QT :4 0 5± 4 4vs3 97+3 0ms .QTc :4 48± 4 7vs4 2 4± 2 6ms ,QTD 2 9± 1 7vs2 7± 1 6ms ,QTcD :2 8±1 9vs2 6± 1 8ms ,P >0 .0 5) ,但与前两对照组比 ,胺碘酮明显延长QT期间并使QTD增大 (QT :4 65± 53vs4 0 5± 4 4or3 97± 3 0ms ,QTc :4 49± 54vs4 48± 4 7or 4 2 4± 2 6ms ,QTD :4 7± 2 0vs2 9± 1 9or 2 7± 1 6ms ,QTcD :4 9± 2 1vs2 8± 1 9or 2 6± 1 8ms ,P <0 .0 1 )。结论 :胺碘酮不仅延长心肌复极 ,且使复极离散。
OBJECTIVE:This study evaluated the effects of amiodarone on the myocardial repolarization in the patients with atrial fibrillation.METHODS:QT dispersions measured from 12 lead standard surface ECG were retrospectively assessed in 48 patients treated with Amiodarone,and compared with that of paroxysmal atrial fibrillation and health groups.RESULTS:No disparity in QT interval and QT dispersion was found between paroxysmal atrial fibrillation and health group(QT:405±44vs397+30ms.QTc:448±47vs424±26ms,QTD 29±17vs27±16ms,QTcD:28±19vs26±18ms,P>0.05).However,compared with these two group,we found that both of the QT interval and QT dispersion significantly increased in Amiodarone group(QT:465±53vs405±44 or 397±30ms,QTc:449±54vs448±47 or 424±26ms,QTD:47±20vs29±19 or 27±16ms,QTcD:49±21vs28±19 or 26±18ms,P<0.01).CONCLUSION:Amiodarone not only effectively control atrial fibrillation with QT interval prolongation but also increased QT dispersion.
出处
《中国现代应用药学》
CAS
CSCD
2000年第3期234-236,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
胺碘酮
心房纤颤
QT离散度
QT间期
amiodarone,atrial fibrillation,QT dispersion,QT interval
