摘要
目的 探讨99Tcm 甲氧基异丁基异腈 (MIBI)乳房亲肿瘤显像鉴别诊断乳房肿瘤良恶性及诊断腋淋巴结转移的临床价值。方法 46例乳房肿块病人 ,其中 2 7例恶性肿瘤 ,19例良性病变 ,在手术前 15d内进行99Tcm MIBI乳房亲肿瘤显像。病变乳房对侧肘前静脉注射99Tcm MIBI 740MBq后 5min ,分别采集俯卧位两侧乳房后斜位图像及仰卧位胸部前位图像。乳房内和 (或 )腋窝区出现异常放射性浓聚影为阳性 ,并与手术后病理检查结果对照。结果 手术发现乳房肿块最小直径为1 5cm ,最大为 8 0cm ;腋窝转移淋巴结最小直径为 0 5cm ,最大 2 0cm。99Tcm MIBI乳房亲肿瘤显像对乳房肿瘤良恶性鉴别的灵敏度为 10 0 % ,特异性为 6 8 4% ;对腋窝淋巴结转移的诊断灵敏度为84 6 % ,特异性为 97 0 %。其中 1例乳腺癌病人 ,显像发现对侧腋窝淋巴结有转移。结论 99Tcm MIBI乳房亲肿瘤显像不仅能鉴别诊断乳房肿瘤的性质 。
Objective To investigate the clinical value of 99 Tc m MIBI scintimammography both in differentiating malignant breast cancer from benign breast mass and in detecting axillary lymph nodes metastasis Methods A group of 46 patients with palpable masses (including 27 patients with breast cancer, 19 patients with benign disease) underwent 99 Tc m MIBI scintimammography within 15 d before surgery Images of two posterior oblique (prone imaging) views and one anterior (supine)planar thoracic view with both axilla included in the field of view were obtained 5 min after injection of 740 MBq of 99 Tc m MIBI (5 min/view)into the vein in the arm contralateral to the sick breast The scintimammography was read as positive when focal radioactivity increased in the breast or (and) axilla The scintigraphy studies were compared with pathology Results Pathological studies showed that the size range of tumor was 1 5 cm～8 0 cm, and the size range of metastatic axillary lymph node was 0 5 cm to 2 0 cm The sensitivity of 99 Tc m MIBI scintimammography in diagnosing breast cancer was 100%, and specificity is 68 4%, and that in detecting axillary lymph node involvement was 84 6% and 97 0%, respectively Conclusions 99 Tc m MIBI scintimammography not only can differentiate the malignant from benign breast tumors, but also can detect the metastases in axillary lymph nodes Combined with other imaging modalities, it has greater clinical significance in diagnosis and management of breast cancer
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2000年第3期124-126,共3页
Chinese Journal of Nuclear Medicine
关键词
乳腺癌
肿瘤转移
放射性核素显像
淋巴结转移瘤
Mammary neoplasms
Lymph nodes
Neoplasm metastasis
Radionuclide imaging
MIBI
