摘要
目的分析糖皮质激素在创伤致急性呼吸窘迫综合征(Acute respiratory distress syndrome,ARDS)中的临床疗效。方法分析我院收治的急性呼吸窘迫综合征患者127例,随机数字法分为观察组70例和对照组57例,即常规治疗的基础上加用糖皮质激素组,比较两组治疗后患者的氧合指数、APACHEⅡ评分、HR、尿量,炎性因子IL-1、IL-6、CRP、TNF-α水平,以及机械通气时间、住院时间、死亡率。结果治疗后两组氧合指数、APACHEⅡ评分、HR、尿量水平均显著好于治疗前,P<0.05,且观察组与对照组比较,P<0.05。治疗后两组IL-1、IL-6、CRP、TNF-α水平均显著好于治疗前,P<0.05,且观察组与对照组比较,P<0.05。观察组与对照组在机械通气时间、住院时间、死亡率方面比较,均显著缩短,P<0.05。结论糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的有显著的临床价值,促进患者的预后。
Objective To evaluate the clinical efficacy of glucocorticoid in the treatment of patients with acute respiratory distress syndrome（ARDS） caused by trauma.Methods 127 ARDS patients from January 1998 to December 2012 were randomly divided into 2 groups.All patients were given the conventional treatment,and the observation group（57 cases） was treated with glucocorticoid additionally.Oxygenation index,APACHE Ⅱ score,heart rate,urinary production,IL-1,IL-6,CRP,TNF-α,duration of mechanical ventilation and hospital stay,and mortality were compared between the two groups.Results All patients were improved after the treatment,and the improvement of oxygenation index,APACHE Ⅱ score,heart rate,urinary production,IL-1,IL-6,CRP,TNF-α,duration of mechanical ventilation and hospital stay,and mortality was more pronounced in the observation group than in the control group（P〈0.05）.Conclusion Glucocorticoid has a significant clinical value in the treatment of ARDS patients caused by trauma and it can obviously improve their prognosis.
出处
《临床肺科杂志》
2013年第7期1260-1261,共2页
Journal of Clinical Pulmonary Medicine
关键词
急性呼吸窘迫综合征
糖皮质激素
创伤
acute respiratory distress syndrome
glucocorticoid
trauma
