摘要
目的探讨病毒感染与冠心病的相关性,并对其危险因素进行调查研究,为临床预防治疗提供依据。方法共纳入120例入住心内科的冠心病患者,采用统一的调查表详细记录基本信息及相关病史,冠心病患者发生病毒感染的为病例组,选取有病毒感染未发生冠心病的患者作为对照组,应用多因素回归分析对病毒感染发生冠心病的相关危险因素进行研究。结果 120例冠心病患者中有100例冠心病患者发生病毒感染,占83.3%;病毒感染患者发生冠心病的单因素分析结果显示,发生组高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)及空腹血糖(FBG)分别为(1.4±0.5)mmol/L、(3.5±2.3)mmol/L、(2.3±0.3)mmol/L、(5.6±0.7)mmol/L、(9.4±3.2)mmol/L,未发生组分别为(0.9±0.3)mmol/L、(5.3±3.0)mmol/L、(1.7±0.4)mmol/L、(4.7±0.6)mmol/L、(6.4±4.2)mmol/L,两组比较,差异有统计学意义(P<0.05);LDL-C是病毒感染患者发生冠心病的独立危险因素,而HDL-C是病毒感染患者发生冠心病的保护因素(P<0.05)。结论病毒感染与冠心病的发生存在相关性,血清LDL-C及HDL-C水平的异常可以进一步促进病毒感染患者冠心病的发生,临床工作中,对于该类患者要严格控制其血脂水平。
OBJECTIVE To explore the correlation between the virus infections and coronary heart disease and its risk factors so as to provide basis for the clinical prevention and treatment. METHODS The participants included 120 cases of coronary heart disease patients in the cardiology department , the unified questionnaires were employed to record the basic information. The coronary heart disease patients with the viral infections were select- ed as the case group, and the cases who were with the viral infections but were without coronary heart disease were set as the control group. The multivariate regression analysis was performed for the risk factors of the viral infections in the patients with coronary heart diseases. RESULTS Of totally 120 cases of coronary heart diseases, the viral infections occurred in 100 cases with the incidence of 83.3%. The univariate analysis indicated that the HDL-C, LDL-C, TG, TC, and FBG of the case group were respectively （1. 4±0. 5） mmol/L, （3. 5±2. 3） mmol/L, （2.3±0.3） mmol/L, （5.6±0.7） mmol/L, and （9.4±3.2） mmol/L and were respectively （0.9±0. 3） retool/L, （5.3±3.0） mmol/L, （1.7 ± 0.4） mmol/L, （4.7 ± 0.6） retool/L, and （6.4 ± 4.2） mmol/L in the control group, the differences between the two groups were statistically significant （P〈0.05）. The LDL-C was the independent risk factor of the coronary heart disease in the patients with viral infections, and the HDL-C was the protective factor. CONCLUSION There is correlation between the viral infection and the coronary heart disease, the abnormal level of serum LDL-C or HDL-C can further promote the occurrence of coronary heart dis-ease in the patients with viral infections, thus it is necessary for the patients to rigidly control the level of blood lipid during the clinical treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第11期2564-2566,共3页
Chinese Journal of Nosocomiology
关键词
冠心病
病毒感染
危险因素
多因素分析
Coronary heart disease
Virus infection
Risk factor
Multivariate analysis
