摘要
目的:探讨四逆汤对大鼠"温里"药效的性别差异。方法:选用温里剂代表方四逆汤灌胃SD大鼠,观察不同性别大鼠体质量、饮水量、饮食量、游泳时间以及内分泌代谢性指标儿茶酚胺,17-羟皮质类固醇(17-OHCS),甲状腺素T3、T4。结果:四逆汤能够增加大鼠的体质量、饮水量、饮食量;延长游泳时间;尿内儿茶酚胺、17-OHCS排出量增多;血清内甲状腺素T3、T4含量增加,雄性较雌性更为显著。结论:四逆汤对大鼠的"温里"药效存在性别差异。
Objective：To reveal and study the gender differences of Sini Decoction on rats ＂interior-warming＂ efficacy.Methods：Selected Sini Decoction for the representative of the hot formulas for SD rats intragastric administration,and observed the weight,water intake,food intake,swimming time,endocrine and metabolic indicators for catecholamine,17-OH corticosteroids（17-OHCS）,and thyroid hormone T3,T4 of the different sex rats.Results：Sini Decoction can increase body weight,water intake,food intake of the rats,extend the swimming time and increase the urine catecholamine,17-OHCS excretion.The decoction also can increase serum thyroid hormone T3 and T4 content,and the contents increase of male are more significant than that of female.Conclusion：Sini Decoction on rats ＂interior-warming＂ efficacy have function of gender differences.
出处
《中医学报》
CAS
2013年第6期844-846,共3页
Acta Chinese Medicine
基金
江苏省方剂重点学科开放课题资助项目(编号:2011FJ5001)
江苏省高校优势学科建设工程资助项目(编号:PAPD)
关键词
四逆汤
温里
性别差异
大鼠
sini decoction
interior-warming
gender differences
rat
