摘要
目的探讨高同型半胱氨酸血症在脑血管性痴呆中的临床意义。方法选择本院2009年8月至2012年8月脑血管痴呆患者共60例,作为痴呆组,其中轻度痴呆患者共19例,中度痴呆患者32例,重度痴呆患者9例。同时选择同期到本院体检的健康者共40例,作为对照组。测定两组同型半胱氨酸水平。结果痴呆组同型半胱氨酸水平高于对照组,差异有统计学意义(P<0.05);重度痴呆患者同型半胱氨酸水平高于中度痴呆患者,差异有统计学意义(P<0.05);中度痴呆患者同型半胱氨酸水平高于轻度痴呆患者,差异有统计学意义(P<0.05)。结论血浆同型半胱氨酸水平升高可能是导致血管性痴呆的一种危险因素,且随着痴呆程度增加,其水平越高。
Objective To investigate the clinical significance of homocysteine in patients with vascular dementia. Methods 60 patients with cerebral vascular dementia were selected from August , 2009 to August, 2012 , dementia group including mild dementia patients with a total of 19 cases, 32 cases of patients with moderate dementia, 9 cases of patients with severe dementia.40 cases with physical health were selected during the same period as control grouip, homocysteine levels was detected in two groups. Results The dementia group homocysteine levels were higher than that in the control group, the difference was statistically significant （P0.05） ;the homocysteine level in patients with severe dementia was higher than that in in patients with moderate dementia, the difference was statistically significant （P0.05）;the homocysteine level in patients with moderate dementia was higher than that in in patients with mild dementia, the difference was statistically significant （P0.05）. Conclusion Hyperhomocystinemia may be risk factor for vascular dementia,and the level of plasma homocysteine is more higher,and the degree of dementia is more higher.
出处
《中国现代药物应用》
2013年第12期32-33,共2页
Chinese Journal of Modern Drug Application
