摘要
目的调查成都地区体检人群甲状腺功能异常及血脂异常的情况。方法选择8310例进行健康体检并接受甲状腺功能及血脂检测的成都地区人员。设计统一调查表。受检人员清晨空腹取静脉血,检测血清促甲状腺激素(TSH)、游离甲状腺素3(FT3)、FT4、血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。将受检者按血脂水平高低分为血脂升高、血脂边缘升高和血脂正常组,对数据进行统计学分析。结果在8310名受调查者中,甲状腺功能亢进(甲亢)、甲状腺功能减退(甲减)、亚临床甲亢及亚临床甲减的诊断符合率分别为0.39%、1.20%、0.52%及16.19%。甲亢、甲减和亚临床甲减的女性患病率均高于男性(P<0.05)。血脂升高组、血脂边缘升高组及对照组分别有100例(44.8%)、145例(53.1%)及66例(22.3%)受调查人员的甲状腺功能异常。3组人员TSH水平的差异有统计学意义(P<0.01),但FT3、FT4水平的差异无统计学意义(P>0.05)。相关分析表明,年龄与TSH(r=0.169,P<0.01)、总胆固醇(r=0.194,P<0.01)及HDL-C(r=0.142,P<0.01)呈正相关,与FT3((r=-0.223,P<0.01)、FT4(r=-0.258,P<0.01)及三酰甘油(r=-0.012,P<0.01)呈负相关。结论成都地区甲状腺功能紊乱以甲减和亚临床甲减为主,女性患病率高于男性,血脂异常者患病率高于正常人群。
Objective To investigate situation of thyroid dysfunction and dyslipidemias of physical examination people in Chendu region.Methods 8 310 people in Chengdu region who had undergone physical examination including thyroid function and serum lipid testing were selected.Unified questionnaire was designed.Their fasting venous blood samples were collected at early morning.Serum thyroid stimulating hormone（TSH）,free thyroxin 3（FT3）,FT4,total cholesterol,triglycerides,low density lipid-cholesterol（LDL-C） and high density lipid-cholesterol（HDL-C） were detected.These people were divided into high serum lipid,borderline high serum lipid and normal serum lipid group according to their serum lipid level,and the data were statistically analyzed.Results Among 8 310 people who had been investigated,diagnostic accordance rate of hyperthyroidism,hypothyroidism,subclinical hyperthyroidism and subclinical hypothyroidism were 0.39%,1.20%,0.52% and 16.19%,respectively.Female prevalence of hyperthyroidism,hypothyroidism and subclinical hypothyroidism were higher than male（P＆lt;0.05）.High serum lipid,borderline high serum lipid and normal serum lipid group demonstrated 100（44.8%）,145（53.1%） and 66（22.3%） people suffering from thyroid dysfunction,respectively.Statistical difference of serum TSH levels was found among the three groups（P＆lt;0.01）,however,FT3,FT4 levels showed no statistical difference（P＆gt;0.05）.Correlation analysis showed that age was positively correlated with TSH（r=0.169,P＆lt;0.01）,total cholesterol（r=0.194,P＆lt;0.01） and HDL-C（r=0.142,P＆lt;0.01）,and negatively correlated with FT3（r=-0.223,P＆lt;0.01）,FT4（r=-0.258,P＆lt;0.01） and triglycerides（r=-0.012,P＆lt;0.01）.Conclusion Hypothyroidism and subclinical hypothyroidism are major thyroid dysfunction in Chengdu region,with higher female prevalence than male,and higher prevalence of those with dyslipidemias than normal population.
出处
《国际检验医学杂志》
CAS
2013年第9期1103-1105,共3页
International Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(81100303)
四川省科技厅支撑项目(2011SZ0158)
