摘要
目的分析医院内革兰阴性杆菌的分布及其耐药状况,为临床合理用药提供依据。方法对该院检出的441株革兰阴性杆菌采用细菌编码鉴定及药敏分析系统测试板进行鉴定与微生物敏感性试验。结果在分离的革兰阴性杆菌中,以大肠埃希菌、肺炎克雷伯菌、鲍氏不动杆菌和铜绿假单胞菌4种细菌为主。大肠埃希菌在尿液、腹腔引流液及血液标本中分离率较高;肺炎克雷伯菌、鲍氏不动杆菌和铜绿假单胞菌在痰液标本中的分离率较高。大肠埃希菌产生超广谱β-内酰胺酶(ESBL)的百分比为60.7%,显著高于肺炎克雷伯菌(19.0%)。耐药性由高到低依次为大肠埃希菌、鲍氏不动杆菌、肺炎克雷伯菌和铜绿假单胞菌。结论加强对临床分离的主要病原菌的耐药性监测有利于抗菌药物的合理使用,减缓多重耐药菌株的出现。
Objective To analyze the distribution and drug resistance of Gram-negative bacilli in hospital and to provide a basis for rational drug use clinically.Methods Identification and microbial sensitivity tests were performed upon 441 Gram-negative bacilli isolated from the hospital by bacterial coding identification and drug susceptibility analysis system test board.Results Among Gram-negative bacilli isolated,Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii and Pseudomonas aeruginosa were the four major bacteria.Escherichia coli from urine,abdominal drainage fluid,blood samples,and Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa from sputum samples showed higher isolating rates.Percentage of extended-spectrum β-lactamase（ESBL） produced by Escherichia coli was 60.7%,which was higher than that of Klebsiella pneumoniae（19.0%）.Top-ranked drug resistance in descending order were of Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii and Pseudomonas aeruginosa.Conclusion Enhancement of monitoring drug resistance of main pathogens isolated clinically is conducive to rational use of antimicrobial drugs and retarding the emergence of multi-resistant strains.
出处
《国际检验医学杂志》
CAS
2013年第9期1106-1107,1109,共3页
International Journal of Laboratory Medicine
关键词
革兰阴性杆菌
抗药性
微生物
微生物敏感性试验
医院
Gram-positive rods
drug resistance,microbial
microbial sensitivity tests
hospital
