摘要
目的了解东莞地区近3年尿路感染病原菌分布及其耐药性特点,为临床提供合理应用抗菌药物的依据。方法收集该院2010～2012年1 557株尿路感染患者中段尿标本分离的病原菌,用VITEK32细菌鉴定仪进行鉴定,并采用K-B法进行药敏试验,参照2010年CLSI标准判读结果。结果该院2010～2012年尿液标本共分离出1 557株病原菌,革兰阴性杆菌中以大肠埃希菌、肺炎克雷伯菌为主,分别占42.7%、6.2%。未发现碳氢酶烯类药物耐药株,这两种菌对含酶抑制剂药的耐药率都偏低,对氨苄西林的耐药率较高。革兰阳性球菌以粪肠球菌、屎肠球菌为主,分别占9.2%、3.5%。除四环素以外,屎肠球菌对其他抗菌药物的耐药率均高于粪肠球菌。未发现利奈唑胺和万古霉素的耐药株,这两种菌对红霉素和四环素的耐药率较高。结论临床医生应结合本地区尿路感染病原菌分布特征及药敏试验结果合理应用抗菌药物。
Objective To investigate the bacteria distribution and drug resistace analysis of urinary tract infection in dongguan between 2010-2012,and provide the credible evidence for clinic medicine usage.Methods 1557 strains of pathogens from urinary specimens were isolated and cultured from the patients in hospital between 2010-2012,the total 1557 strains of pathogens were identified by VITEK 32 and the drug resistace was tested by K-B method.Results 1 557 strains of pathogens were isolated from urinary specimens in hospital between 2010-2012,Most Gram negative bacilli were Escherichia coli,Klebsiellar pneumonia,detection rates of they were 42.7% and 6.2%.Carbopenems-resistant bacteria was not found.E.coli and K.pneumonia demonstrated lower resistance rate to β-lactamase inhibitors,and higher resistance rate to ampicillin.Most Gram positive bacilli were Enterococcus faecalis and Enterococcus faecium,detection rates of they were 9.2% and 3.5%.The resistance rate of E.faecium is higher than E.faecalis,except tetracyclines.Vancomycin and linezolid resistant bacteria was not found.E.faecium and E.faecalis demonstrated higher resistance rate to erythromycin and tetracyclines.Conclusion Clinical doctors should pay attention to the detection and drug resistance of pathogens in urinary tract infection and use antibiotica reasonably.
出处
《国际检验医学杂志》
CAS
2013年第10期1244-1245,1248,共3页
International Journal of Laboratory Medicine
基金
广东省东莞市科技局资助项目(201110515046224)
关键词
泌尿道感染
抗菌药
药物耐受性
革兰氏阴性菌
革兰氏阳性菌
urinary tract infections
anti-bacterial agents
drug tolerance
gram-negative bacteria
gram-positive bacteria
