摘要
目的:探讨舒郁九宝丸治疗伴有抑郁状态的胃食管反流病(GERD)的临床疗效。方法:52例符合纳入标准的GERD患者,随机分为治疗组和对照组,各26例。对照组给予泮托拉唑、氟西汀口服治疗,治疗组给予舒郁九宝丸口服治疗。应用胃食管反流病症状分级进行疗效判定,并采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、抗抑郁药副反应量表(SERS)对两组患者进行评估。结果:治疗组总有效率为92.31%,对照组为88.46%,两组比较差异无统计学意义(P>0.05);两组患者SAS、SDS评分均明显低于治疗前(P<0.05),两组治疗后组间比较,差异无统计学意义(P>0.05);治疗组的不良反应发生例数明显低于对照组(P<0.05),SERS评分亦明显低于对照组(P<0.05)。结论:舒郁九宝丸能有效的改善GERD患者焦虑、抑郁负性情绪,起到泮托拉唑与氟西汀合用的治疗效果,且不良反应少。
Objective： To evaluate the clinical effects of Shuyu Jiubao Pill in the treatment of gastroesophageal reflux disease（GERD） accompanied with anxiety and depression. Methods： 52 cases were randomly divided into control and experimental groups, with 26 cases in each group. The patients in control group received treatment with Pantoprazole combined with Florentine, while patients in experimental group were made the use of Shuyu Jiubao pill. Clinical efficacy was assessed with gastroesophageal reflux symptoms, and the score of patients was assessed by self - rating anxiety scale （ SAS）, self - rating depression scale （SDS） and rating scale for side effects （SERS）. Results ： After treatment, the total effective rate was 92.31% in the experimen- tal group and 88.46% in the control group with no significant difference between two groups （P 〉0.05）. The scores of both SAS and SDS in the experimental group after treatment were much lower than those before treatment （ P 〈 0.05 ） , with no significant difference compared with the control group （ P 〉 0.05 ） , and the cases of conducting side effect and the scores of SERS were lower than those in the control group （ P 〈 0.05 ）. Conclusion ：Shuyu Jiubao pill can help to improve the patientg anxiety and depression, which can show the same clinical efficacy of Pantoprazole combined with Florentine with few side effects.
出处
《中医药信息》
2013年第3期68-71,共4页
Information on Traditional Chinese Medicine
关键词
舒郁九宝丸
胃食管反流病
焦虑
抑郁
Shuyu Jiubao pill
Gastroesophageal reflux disease
Anxiety
Depression
